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This study is aimed at developing and validating molecular assays to detect resistance genes belonging to the\n                    <jats:italic>bla<\/jats:italic>\n                    family in resistant\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    isolates. The genes included belong to the subfamilies:\n                    <jats:italic>bla<\/jats:italic>\n                    SHV\n                    <jats:italic>, bla<\/jats:italic>\n                    TEM\n                    <jats:italic>, bla<\/jats:italic>\n                    NDM\n                    <jats:italic>, bla<\/jats:italic>\n                    KPC\n                    <jats:italic>, bla<\/jats:italic>\n                    GES\n                    <jats:italic>, bla<\/jats:italic>\n                    CTX\u2010M, and relevant variants of the\n                    <jats:italic>bla<\/jats:italic>\n                    OXA subfamily. The identified genotypic profile showed a high prevalence of genes belonging to Ambler\u2032s classes of beta\u2010lactamases A, B, and D, which was in accordance with the phenotypic results obtained for the isolates investigated. A high prevalence of resistance to penicillins, cephalosporins, and carbapenems was observed. In conclusion, the assays developed were efficient in detecting the main resistance genes of the\n                    <jats:italic>bla<\/jats:italic>\n                    family in\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    , revealing a concerning regional burden of resistance genes.\n                  <\/jats:p>","DOI":"10.1155\/ijm\/2707907","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T09:24:12Z","timestamp":1769678652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insights of\n                    <i>\u03b2<\/i>\n                    \u2010Lactams Resistance in\n                    <i>Klebsiella pneumoniae<\/i>\n                    Clinical Isolates: A Focus on Molecular Identification of Drug Resistance"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5008-8181","authenticated-orcid":false,"given":"Lavouisier F. 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