{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T01:01:38Z","timestamp":1781830898859,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":111,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020A1515011183"],"award-info":[{"award-number":["2020A1515011183"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401650"],"award-info":[{"award-number":["81401650"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Microbiology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Atopic dermatitis (AD) is a chronic and inflammatory disease with an immunogenetic basis that can be triggered by extrinsic and intrinsic factors, including dysbiosis of the skin microbiota. The lipophilic\n                    <jats:italic>Malassezia globosa<\/jats:italic>\n                    is one of the dominant fungal species on the skin of AD patients.\n                    <jats:italic>Malassezia<\/jats:italic>\n                    and the host pathophysiologic mechanism underlying its role in exacerbating AD symptoms remain to be elucidated. This experiment established a fungal overgrowth model by topical administration suspension of\n                    <jats:italic>M. globosa<\/jats:italic>\n                    on BALB\/c mice (M group) and MC903\u2010induced AD model (AD+M group). Our results suggested that more severe AD\u2010like lesions and higher dermatitis scoring were observed in the AD+M group compared with the AD group. The expression of TSLP mRNA in the tissue and serum IgE were highly increased in the AD group, while decreased significantly in the AD+M group. The expression levels of IL\u201017A and IL\u201022 in ear tissues and serum were significantly increased with\n                    <jats:italic>M. globosa<\/jats:italic>\n                    stimulation, especially in the AD+M group. Meanwhile, the percentage of Th17 and Th22 cells in the spleen were positively correlated with IL\u201017A and IL\u201022 levels in the serum. In contrast, IFN\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    and IL\u20104 production were significantly decreased in the AD+M group compared with the AD group. This study demonstrated that overgrowing\n                    <jats:italic>M. globosa<\/jats:italic>\n                    could aggravate AD symptoms and that IL\u201017A and IL\u201022 may be involved in the process. The promotion of IL\u201017A and IL\u201022 production induced by\n                    <jats:italic>M. globosa<\/jats:italic>\n                    may restrain the development of TSLP and inhibit the Th1\/Th2 type skin inflammation.\n                  <\/jats:p>","DOI":"10.1155\/ijm\/3586621","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T09:49:19Z","timestamp":1745315359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of\n                    <i>Malassezia globosa<\/i>\n                    on the Expression of Thymic Stromal Lymphopoietin and Differentiation of T Helper Cells in MC903\u2010Induced Atopic Dermatitis Mouse 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