{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T06:59:07Z","timestamp":1785481147684,"version":"3.56.0"},"reference-count":76,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":210,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 111-2621-B-018-001"],"award-info":[{"award-number":["MOST 111-2621-B-018-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Microbiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by microbial imbalance, particularly the overgrowth of\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    . This study reports the green synthesis of silver nanoparticles (AgNPs) using\n                    <jats:italic>Macaranga tanarius<\/jats:italic>\n                    extract (MTE) and evaluates their in vitro antibacterial and bioactive properties. The synthesized MT\u2010AgNPs exhibited a distinct surface plasmon resonance (SPR) peak at 430\u2009nm, with TEM revealing predominantly spherical morphologies (mean size: 29.2\u2009nm; range: 6\u201387\u2009nm). Phytochemical analysis confirmed that MTE is rich in polyphenols (2429 \u00b1 33.7\u2009mg GAE\/100\u2009g) and flavonoids (236.3 \u00b1 10.7\u2009mg QE\/100\u2009mL), contributing to its strong antioxidant capacity (82.72\n                    <jats:italic>%<\/jats:italic>\n                    \u00b1 3.12\n                    <jats:italic>%<\/jats:italic>\n                    DPPH scavenging; FRAP: 20.36 \u00b1 0.02\u2009mg FeSO\n                    <jats:sub>4<\/jats:sub>\n                    \/100\u2009mL). MT\u2010AgNPs demonstrated potent antibacterial activity against 17 clinical\n                    <jats:italic>S. aureus<\/jats:italic>\n                    isolates (e.g.,\n                    <jats:italic>mecA<\/jats:italic>\n                    \u2010positive strains), with MICs of 9.375\u201318.75\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\/mL. At 6.25\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\/mL, MT\u2010AgNPs significantly inhibited biofilm formation by up to 63% (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Crucially, MTE displayed a highly stable tyrosinase inhibitory profile, maintaining a consistent inhibition rate of approximately 45% throughout a 120\u2010min kinetic assay (equivalent to 6.0\u20138.5\u2009mg kojic acid\/g). This sustained inhibitory stability suggests its potential application in addressing postinflammatory hyperpigmentation. These findings indicate that MT\u2010AgNPs serve as a promising, eco\u2010friendly antibacterial nanomaterial with potential in vitro applications for managing AD\u2010related microbial challenges and skin recovery.\n                  <\/jats:p>","DOI":"10.1155\/ijm\/3943779","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T06:20:39Z","timestamp":1785478839000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Green Synthesis of Silver Nanoparticles From\n                    <i>Macaranga tanarius<\/i>\n                    (L.) Mull. Arg. 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