{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:52:42Z","timestamp":1791010362998,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":274,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Microbiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    The taxonomic position of an actinomycete, strain 15\u2010116A\n                    <jats:sup>T<\/jats:sup>\n                    , isolated from a blood culture of a 31\u2010year\u2010old male from the United States was determined using polyphasic taxonomic analysis. Genome\u2010based phylogeny showed that the strain was closely related to\n                    <jats:italic>Streptomyces composti<\/jats:italic>\n                    ,\n                    <jats:italic>Streptomyces thermocarboxydovorans<\/jats:italic>\n                    , and\n                    <jats:italic>Streptomyces thermospinosisporus<\/jats:italic>\n                    species. Digital DNA\u2013DNA (dDDH) relatedness and average nucleotide identity (ANI) between the draft genome sequence of the strain and those of its closest phylogenomic neighbors listed above were between 35.9% and 37.3% (&lt;\u200970%) and 88.5%, 88.1%, and 88.6% (95%\u201396.7%), respectively. However, the dDDH and ANI values between the genome sequence of\n                    <jats:italic>S. thermocarboxydovorans<\/jats:italic>\n                    JCM 10367\n                    <jats:sup>T<\/jats:sup>\n                    and\n                    <jats:italic>S. thermospinosisporus<\/jats:italic>\n                    JCM 11756\n                    <jats:sup>T<\/jats:sup>\n                    were 72.3% and 96.7%, respectively. These values are above the defined thresholds for prokaryotic species demarcation (70% dDDH and 95%\u201396.7% ANI) and fall within the dDDH range of 70%\u201379% for subspecies designation. Based on these findings and in accordance with the priority rule in nomenclature,\n                    <jats:italic>S. thermospinosisporus<\/jats:italic>\n                    is considered a later heterotypic synonym of\n                    <jats:italic>S. thermocarboxydovorans<\/jats:italic>\n                    and is classified as a subspecies of\n                    <jats:italic>S. thermocarboxydovorans<\/jats:italic>\n                    , for which the name\n                    <jats:italic>S. thermocarboxydovorans<\/jats:italic>\n                    subsp.\n                    <jats:italic>thermospinosisporus<\/jats:italic>\n                    subsp. nov. is proposed. Consequently,\n                    <jats:italic>S. thermocarboxydovorans<\/jats:italic>\n                    subsp.\n                    <jats:italic>thermocarboxydovorans<\/jats:italic>\n                    is created. Strain 15\u2010116A\n                    <jats:sup>T<\/jats:sup>\n                    was characterized by the presence of\n                    <jats:italic>LL<\/jats:italic>\n                    \u2010diaminopimelic acid in its peptidoglycan; diphosphatidylglycerol, phosphatidylethanolamine, and phosphatidylinositol as the major phospholipids; MK\u20109(H\n                    <jats:sub>8<\/jats:sub>\n                    ) and MK\u20109(H\n                    <jats:sub>6<\/jats:sub>\n                    ) as the predominant menaquinones (&gt;\u200910%); and\n                    <jats:italic>iso-<\/jats:italic>\n                    C\n                    <jats:sub>15:0<\/jats:sub>\n                    ,\n                    <jats:italic>anteiso<\/jats:italic>\n                    \u2010C\n                    <jats:sub>15:0<\/jats:sub>\n                    ,\n                    <jats:italic>iso-<\/jats:italic>\n                    C\n                    <jats:sub>16:0<\/jats:sub>\n                    , and\n                    <jats:italic>anteiso-<\/jats:italic>\n                    C\n                    <jats:sub>17:0<\/jats:sub>\n                    as the major fatty acids (&gt;\u200910%). Morphological, phenotypic, and genomic traits distinguished strain 15\u2010116A\n                    <jats:sup>T<\/jats:sup>\n                    from its closest phylogenetic neighbors and highlighted the assignment of strain 15\u2010116A\n                    <jats:sup>T<\/jats:sup>\n                    (=\u2009DSM 106436\n                    <jats:sup>T<\/jats:sup>\n                    \u2009=\u2009ATCC BAA\u20102935\n                    <jats:sup>T<\/jats:sup>\n                    ) to a novel species of the genus\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    , for which the name\n                    <jats:italic>Streptomyces sanguinis<\/jats:italic>\n                    sp. nov. is proposed. Genome screening for virulence factor\u2010associated genes showed that the strain harbored a gene encoding isocitrate lyase, which is required for persistent infection of\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (YP_177728), as well as gene clusters associated with phenazine biosynthesis (NP_252902), unlike its close relatives. Moreover, strain 15\u2010116A\n                    <jats:sup>T<\/jats:sup>\n                    possessed a gene encoding elongation factor Tu (WP_003028672), which plays an important role in the bacterium\u2032s ability to adhere to host cells. However, further experimental studies are required to evaluate the pathogenic potential of this strain.\n                  <\/jats:p>","DOI":"10.1155\/ijm\/5214822","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:00:56Z","timestamp":1791007256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Streptomyces sanguinis<\/i>\n                    sp. nov., a Ceftriaxone\u2010Resistant Strain Obtained From Human Blood and Reclassification of\n                    <i>Streptomyces thermospinosisporus<\/i>\n                    as\n                    <i>Streptomyces thermocarboxydovorans<\/i>\n                    subsp.\n                    <i>thermospinosisporus<\/i>\n                    subsp. nov"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7973-7640","authenticated-orcid":false,"given":"Imen","family":"Nouioui","sequence":"first","affiliation":[{"name":"Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures  Braunschweig Germany  dsmz.de"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0672-6999","authenticated-orcid":false,"given":"Jacqueline","family":"Wolf","sequence":"additional","affiliation":[{"name":"Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures  Braunschweig Germany  dsmz.de"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1641-019X","authenticated-orcid":false,"given":"Meina","family":"Neumann-Schaal","sequence":"additional","affiliation":[{"name":"Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures  Braunschweig Germany  dsmz.de"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8754-9829","authenticated-orcid":false,"given":"Christopher A.","family":"Gulvik","sequence":"additional","affiliation":[{"name":"Bacterial Special Pathogens Branch Division of High-Consequence Pathogens and Pathology National Center for Emerging and Zoonotic Infectious Disease Centers for Disease Control and Prevention  Atlanta Georgia USA  cdc.go.kr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6502-6872","authenticated-orcid":false,"given":"John R.","family":"McQuiston","sequence":"additional","affiliation":[{"name":"Bacterial Special Pathogens Branch Division of High-Consequence Pathogens and Pathology National Center for Emerging and Zoonotic Infectious Disease Centers for Disease Control and Prevention  Atlanta Georgia USA  cdc.go.kr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6480-0627","authenticated-orcid":false,"given":"Brent A.","family":"Lasker","sequence":"additional","affiliation":[{"name":"Bacterial Special Pathogens Branch Division of High-Consequence Pathogens and Pathology National Center for Emerging and Zoonotic Infectious Disease Centers for Disease Control and Prevention  Atlanta Georgia USA  cdc.go.kr"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.46.4.337-341.1943"},{"key":"e_1_2_12_2_2","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/978-3-642-30138-4_184","volume-title":"The Prokaryotes: Actinobacteria","author":"K\u00e4mpfer P.","year":"2014"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.005638"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.006943"},{"key":"e_1_2_12_5_2","first-page":"242","article-title":"Towards Minimal Standards for the Description of Streptomyces Species","volume":"8","author":"Manfio G. 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