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Data from the Baltic region remain scarce, limiting infection control and stewardship strategies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted an integrated phenotypic\u2013genotypic analysis of\n                      <jats:italic>A. baumannii<\/jats:italic>\n                      isolates collected from ICU patients in a tertiary\u2010care hospital in Latvia (July 2022\u2013June 2024). Antimicrobial susceptibility testing was performed for major antibiotic classes, and whole\u2010genome sequencing (WGS) was used to identify genomic resistance determinants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analysed 52 clinical isolates from 45 ICU patients. Multidrug resistance was nearly universal (98%), with complete resistance to carbapenems and fluoroquinolones and &gt;\u200995% resistance to aminoglycosides and trimethoprim\u2013sulfamethoxazole. Colistin activity was largely preserved, with resistance detected in only one isolate, despite widespread polymyxin resistance\u2013associated mutations. Genotypic findings were mostly in line with the phenotypic results. All isolates belonged to the ST2 lineage, highlighting clonal homogeneity. No plasmid replicons were detected, suggesting chromosomal elements as the primary resistance drivers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our first integrated dataset in an ICU setting from the Baltic region demonstrates alarming resistance levels and clonal dominance of ST2. Our findings highlight the importance of combining WGS with susceptibility testing for accurate resistance assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijm\/5526340","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:27:12Z","timestamp":1774690032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determinants of Antimicrobial Resistance in\n                    <i>Acinetobacter baumannii<\/i>\n                    Isolates From Intensive Care Patients in Latvia"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4977-3867","authenticated-orcid":false,"given":"Mihails","family":"Dolgusevs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7918-7909","authenticated-orcid":false,"given":"Nityanand","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0047-3644","authenticated-orcid":false,"given":"Oksana","family":"Savicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9067-8912","authenticated-orcid":false,"given":"Reinis","family":"Vangravs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7085-7762","authenticated-orcid":false,"given":"Jevgenijs","family":"Bodrenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6293-0525","authenticated-orcid":false,"given":"Liene","family":"Ostele-Ce\u0161\u0137e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1097-1938","authenticated-orcid":false,"given":"Gustavs","family":"Rind\u017es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7370-0495","authenticated-orcid":false,"given":"Dace","family":"Zemite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3671-1213","authenticated-orcid":false,"given":"Aigars","family":"Reinis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7293-3307","authenticated-orcid":false,"given":"Baiba","family":"Rozentale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,28]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30753-3"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.4161\/viru.19700"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000518"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-16"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad109"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv440"},{"key":"e_1_2_12_7_2","volume-title":"Prioritization of Pathogens to Guide Discovery, Research and Development of New Antibiotics for drug-resistant Bacterial Infections, Including Tuberculosis","author":"World Health Organization","year":"2017"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01388-10"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14010085"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz055"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.001345"},{"key":"e_1_2_12_12_2","volume-title":"Precision Analysis of the carbapenemase- And\/or ESBL-Producing Acinetobacter baumannii Clinical Isolates by the National Microbiology Reference Laboratory in Latvia (P1289)","author":"Kampenusa I.","year":"2025"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1335096"},{"key":"e_1_2_12_14_2","unstructured":"The European Committee on Antimicrobial Susceptibility Testing. 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