{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:35:04Z","timestamp":1787502904255,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":362,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Nephrology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kidney transplant is acknowledged as the treatment of choice for end\u2010stage renal disease (ESRD). This study reports on the outcome of pediatric renal transplant at a tertiary hospital in Abu Dhabi.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>It is a retrospective study of all pediatric renal transplants performed at a single designated pediatric center between February 2010 and February 2024, including children aged 1\u201316\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010nine (44% female) pediatric renal transplants were performed, 36 from living\u2010related donors and 33 from deceased donors. The mean age at transplant and last follow\u2010up were 9.8\u2009\u00b1\u20093.6\u2009years and 13.8\u2009\u00b1\u20094.7\u2009years, respectively. ESRD etiologies included congenital anomalies of the kidney and urinary tract (39%), nephronophthisis (19%), glomerulonephritis (13%), and other causes (29%). Thirteen (19%) children underwent a preemptive transplant, whereas 56 (81%) were on dialysis at transplant. Thirty\u2010one (45%) children had graft rejection: 16 (23%) in the first year, 9 (13%) in years 2\u20135, and 6 (9%) thereafter. Donor\u2010specific antibodies (DSAs) were detected in 19 (28%) children; 17 (25%) of those had graft rejection with anti\u2010DR or anti\u2010DQ alloantibodies. Fourteen children had DSA\u2010negative graft rejection. Of those, eight had cell\u2010mediated rejection, and six had mixed rejection. Predictors of rejection were positive DSA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&lt; 0.0001) and two DR mismatches (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029); three graft losses occurred. The prevalence of EBV, CMV, and BKV infection in the first year was 43%, 39%, and 33%, respectively, falling to 38%, 18%, and 12% in the subsequent years. Thirty\u2010four (49%) children had at least one episode of culture\u2010positive urinary tract infection. The 1\u2010year and 5\u2010year patient survival rates were 100% and 96.6%, and the corresponding graft survival rates were 98.1% and 89.7%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The outcome of pediatric kidney transplants in Abu Dhabi over 14\u2009years shows patient and graft survival comparable to published data. Acute graft rejection remains a major challenge with the presence of DSA and biallelic HLA\u2010DR mismatch as independent predictors for rejection. Optimizing donor selection, immunosuppression, and closer surveillance are vital.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijne\/5188212","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T09:56:01Z","timestamp":1767002161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Evolving Experience and Outcomes of Pediatric Kidney Transplant in Abu Dhabi, UAE (2010\u20132024)"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7077-2338","authenticated-orcid":false,"given":"Ela","family":"Beyyumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4475-7043","authenticated-orcid":false,"given":"Watfa","family":"Al Dhaheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7042-0180","authenticated-orcid":false,"given":"Niaz","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5136-9691","authenticated-orcid":false,"given":"Muhammad Badar","family":"Zaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6072-9659","authenticated-orcid":false,"given":"Eihab Al","family":"Khasawneh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_2_15_1_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2001.00137.x"},{"key":"e_1_2_15_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13856"},{"key":"e_1_2_15_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13566"},{"key":"e_1_2_15_4_2","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2018.03"},{"key":"e_1_2_15_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.248297"},{"key":"e_1_2_15_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2023.10.016"},{"key":"e_1_2_15_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02834.x"},{"key":"e_1_2_15_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3826-x"},{"key":"e_1_2_15_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2021.01.007"},{"key":"e_1_2_15_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12203"},{"key":"e_1_2_15_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13597"},{"key":"e_1_2_15_12_2","article-title":"Kidney Data: the 2022 Annual Data Report of the SRTR","author":"Scientific Registry of Transplant Recipients","year":"2022","journal-title":"Transplantation"},{"key":"e_1_2_15_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13108"},{"key":"e_1_2_15_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.391006"},{"key":"e_1_2_15_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001811"},{"key":"e_1_2_15_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2018.02.187"},{"key":"e_1_2_15_17_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10860917"},{"key":"e_1_2_15_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.816555"},{"key":"e_1_2_15_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071506"},{"key":"e_1_2_15_20_2","doi-asserted-by":"crossref","unstructured":"FichtnerA. 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