{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:55:17Z","timestamp":1791291317965,"version":"4.3.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":278,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Nephrology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prognostic tools for kidney outcomes in ANCA\u2010associated vasculitis (AAV) were developed mainly in European and North American populations, and their performance in Hispanic populations remains less well characterized. ANCA in Latin America (ANCLA) was previously developed and internally validated in a Colombian cohort to predict end\u2010stage kidney disease (ESKD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the prognostic performance of ANCLA with the Berden classification, Renal Risk Score (RRS), Mayo Clinic Chronicity Score (MCCS), and the ANCA Kidney Risk Score (AKRiS) for ESKD prediction in ANCA\u2010associated glomerulonephritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This secondary comparative analysis used the previously described ANCLA derivation cohort of 164 adults with biopsy\u2010proven pauci\u2010immune necrotizing and\/or crescentic glomerulonephritis treated from 2011 to 2024 at a tertiary referral center in Colombia. The five prognostic systems were evaluated in the same population using Kaplan\u2013Meier analyses, Harrell\u2019s C\u2010index, and 1\u2010 and 2\u2010year ROC analyses. Pairwise AUC differences between ANCLA and each comparator were formally assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During a median follow\u2010up of 12.9\u2009months, 63 patients (38.4%) progressed to ESKD. ANCLA showed the most favorable overall discrimination (C\u2010index 0.801; AUC 0.890 at 1\u2009year and 0.896 at 2\u2009years), followed by AKRiS (C\u2010index 0.760) and RRS (0.749); MCCS (0.673) and Berden (0.640) showed lower discrimination. ANCLA had significantly higher AUCs than MCCS and Berden at both horizons, whereas differences versus AKRiS and RRS were smaller. ESKD occurred in 7.3% of the ANCLA low\u2010risk group and 82.5% of the very\u2010high\u2010risk group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this high\u2010risk, predominantly Hispanic Latin American cohort, ANCLA showed the most favorable short\u2010term discrimination, while AKRiS and RRS also performed well. Independent external validation remains necessary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijne\/5595479","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:12:45Z","timestamp":1791288765000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Performance of the ANCLA Risk Score and Established Prognostic Models for Predicting ESKD in ANCA\u2010Associated Glomerulonephritis: A Latin American Cohort"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9533-6214","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Rodelo-Ceballos","sequence":"first","affiliation":[{"name":"Division of Nephrology Hospital San Vicente Fundaci\u00f3n  Medell\u00edn Colombia"},{"name":"Department of Internal Medicine Division of Nephrology University of Antioquia  Medell\u00edn Colombia  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