{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:33:26Z","timestamp":1783985606606,"version":"3.55.0"},"reference-count":70,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":301,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Nephrology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:italic>Tribulus terrestris<\/jats:italic>\n                    has a long\u2010standing historical legacy, having been used for centuries in the treatment of various kidney disorders and other health issues. This research aimed to evaluate the kidney\u2010protective and antioxidant effects of different\n                    <jats:italic>Tribulus terrestris<\/jats:italic>\n                    extracts in ameliorating gentamicin\u2010induced nephrotoxicity in Wistar albino rats. The study included nine rat groups of Wistar rats (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096 per group) treated for 14\u2009days. The control group was given intraperitoneal injections of normal saline and dimethyl sulfoxide (DMSO). Group 2 received subcutaneous gentamicin injections at a dose of 100\u2009mg\/kg for eight days. Groups 3\u20135 were given an intraperitoneal ethanol extract of\n                    <jats:italic>Tribulus terrestris<\/jats:italic>\n                    (EETT) at 150, 300, and 450\u2009mg\/kg, respectively. Groups 6\u20138 received an intraperitoneal acetonitrile extract of\n                    <jats:italic>Tribulus terrestris<\/jats:italic>\n                    (AETT) at 150, 300, and 450\u2009mg\/kg, respectively. Group 9 was administered 200\u2009mg\/kg of intraperitoneal N\u2010acetylcysteine. The results revealed that the EETT exhibited a protective effect against gentamicin\u2010induced renal damage in Wistar albino rats. This protection was shown by reduced kidney tissue damage, lower MDA levels, and increased antioxidant enzyme levels, CAT, and GSH. Moreover, EETT administration dose\u2010dependently improved renal histology, with full recovery observed at 450 mg\/kg, whereas AETT showed no protective effect suggesting a potential dose\u2010dependent effect. Additional studies are necessary to investigate how EETT\u2019s dose\u2013response curve affects its ability to treat kidney damage induced by gentamicin in rats. Conversely, various doses of AETT failed to show a protective effect against gentamicin\u2010induced nephrotoxicity.\n                  <\/jats:p>","DOI":"10.1155\/ijne\/7620700","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:29:18Z","timestamp":1761762558000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ameliorative Effects of\n                    <i>Tribulus Terrestris<\/i>\n                    (Qutayb) Extracts Against Gentamicin\u2010Induced Nephrotoxicity in Wistar Rats"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9018-6205","authenticated-orcid":false,"given":"Ahmed","family":"Al-Mohamadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4230-952X","authenticated-orcid":false,"given":"Imadeldin M. 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