{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:49:57Z","timestamp":1791355797950,"version":"4.3.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":278,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Xerostomia and hyposalivation are common among adults and may significantly influence both oral health and overall quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to analyze patient\u2010related risk factors of xerostomia and hyposalivation in a clinical cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The clinical evaluation included measurements of unstimulated and stimulated salivary flow rates. Furthermore, the xerostomia inventory (XI) was employed, and an additional general question on xerostomia was included. For analyzing associations, nonparametric tests, chi\u2010square tests, correlation analyses, and binary logistic regression were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 116 adult volunteers participated in this study (59.5% women; mean age: 50.2\u2009\u00b1\u200918.7 years). Xerostomia was found in 14.7% of participants, while hyposalivation at rest and under stimulation was detected in 21.6% and 4.3%, respectively. The participants with xerostomia were significantly older (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002), and had fewer remaining teeth (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03). Hyposalivation at rest showed significant correlations with older age, higher number of medications, fewer remaining teeth, lower stimulated salivary flow rate, and higher XI scores (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 &lt; 0.05). Age was the only independent predictor of hyposalivation at rest, while hyposalivation at rest was the strongest predictor of xerostomia in binary logistic regression analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Age, hyposalivation at rest, and XI score are the strongest markers of reduced salivary flow and xerostomia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijod\/3062701","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:55:03Z","timestamp":1791352503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age, Dental State and General Health as Risk Factors for Xerostomia and Hyposalivation"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-5013","authenticated-orcid":false,"given":"Foteini","family":"Spyraki","sequence":"first","affiliation":[{"name":"Division of Gerodontology and Removable Prosthodontics University Clinics of Dental Medicine University of Geneva  Geneva Switzerland  unige.ch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7861-2494","authenticated-orcid":false,"given":"Philippe","family":"Mojon","sequence":"additional","affiliation":[{"name":"Division of Gerodontology and Removable Prosthodontics University Clinics of Dental Medicine University of Geneva  Geneva Switzerland  unige.ch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4094-6955","authenticated-orcid":false,"given":"Najla","family":"Chebib","sequence":"additional","affiliation":[{"name":"Division of Gerodontology and Removable Prosthodontics University Clinics of Dental Medicine University of Geneva  Geneva Switzerland  unige.ch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3981-0134","authenticated-orcid":false,"given":"Frauke","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Division of Gerodontology and Removable Prosthodontics University Clinics of Dental Medicine University of Geneva  Geneva Switzerland  unige.ch"},{"name":"Department of Rehabilitation and Geriatrics University Hospital of Geneva  Geneva Switzerland  hug-ge.ch"},{"name":"Center of Excellence in Precision Medicine and Digital Health Department of Physiology Faculty of Dentistry Chulalongkorn University  Bangkok Thailand  chula.ac.th"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3343-787X","authenticated-orcid":false,"given":"Sabrina","family":"Maniewicz","sequence":"additional","affiliation":[{"name":"Division of Gerodontology and Removable Prosthodontics University Clinics of Dental Medicine University of Geneva  Geneva Switzerland  unige.ch"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1992.tb01084.x"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12238"},{"key":"e_1_2_13_3_2","first-page":"41","article-title":"Dry Mouth: Aging and Oral Health","volume":"2","author":"Navazesh M.","year":"2002","journal-title":"Compendium of Continuing Education in Dentistry"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2017.vol31.0014"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-7325.2006.tb02572.x"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/ger.12497"},{"key":"e_1_2_13_7_2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cden.2015.11.003","article-title":"Hyposalivation and Xerostomia: Etiology, Complications, and Medical Management","volume":"60","author":"Turner M. 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