{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:56:34Z","timestamp":1788900994505,"version":"build-2803163510"},"reference-count":79,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":54,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007797","name":"Helsingin Yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The active matrix metalloproteinase\u20108 (aMMP\u20108) is a functional biomarker of active periodontal tissue destruction. It bridges the gap between clinical findings and underlying biological processes, providing information on active collagen degradation that conventional clinical examinations do not capture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a prospective within\u2010subject clinical study, we assessed point\u2010of\u2010care (PoC) mouthrinse aMMP\u20108 concentrations, periodontal probing depth (PPD), and clinical attachment level (CAL) in 27 adults with stage III\/IV (grade C) periodontitis before and 1 month after anti\u2010infective treatment. aMMP\u20108 PoC results were validated by laboratory western blotting using an independent polyclonal MMP\u20108 antibody.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, 85.2% of samples showed elevated aMMP\u20108 PoC concentrations, declining to 18.5% post\u2010treatment. Baseline aMMP\u20108 was significantly associated with disease severity, correlating with both PPD (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>s<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009=\u20090.39,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.045) and CAL (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>s<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009=\u20090.39,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.042). Following treatment, aMMP\u20108 concentrations decreased significantly (\n                      <jats:italic>V<\/jats:italic>\n                      \u2009=\u2009378,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), with mean reductions of 78.5\u2009\u00b1\u200972.6\u2009ng\/mL (\n                      <jats:italic>d<\/jats:italic>\n                      \u2009=\u2009\u20131.08). Biochemical reductions paralleled clinical improvements, with 100% directional concordance between changes in aMMP\u20108 and changes in PPD and CAL (95% CI 0.87\u20131.00). Reductions in aMMP\u20108 were correlated with improvements in PPD (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>s<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009=\u20090.47,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.014) but not CAL (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>s<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009=\u20090.12,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.544). Linear regression analysis indicated that each 10\u2009ng\/mL reduction in aMMP\u20108 corresponded to an estimated 0.034\u2009mm gain in PPD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings demonstrate that aMMP\u20108 PoC monitoring aligns with both baseline disease severity and short\u2010term periodontal healing. aMMP\u20108 provides an objective biochemical dimension to periodontal assessment, capturing active collagen degradation and serving as a sensitive and clinically meaningful indicator of treatment response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijod\/4285673","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:30:44Z","timestamp":1773009044000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Point\u2010of\u2010Care Biomarker Monitoring of Treatment Efficacy: Changes in Mouthrinse Active Matrix Metalloproteinase\u20108 (aMMP\u20108) Concentrations Following Periodontal Anti\u2010Infective Treatment"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2713-7402","authenticated-orcid":false,"given":"Louis R.","family":"Gieselmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juulia","family":"Rintamarttunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1045-3930","authenticated-orcid":false,"given":"Mutlu","family":"Keskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5821-5299","authenticated-orcid":false,"given":"Ismo T.","family":"R\u00e4is\u00e4nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8817-896X","authenticated-orcid":false,"given":"Taina","family":"Tervahartiala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2219-4689","authenticated-orcid":false,"given":"Tommi","family":"P\u00e4til\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3754-8148","authenticated-orcid":false,"given":"Dirk","family":"Neefs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-0887","authenticated-orcid":false,"given":"Andreas","family":"Pf\u00fctzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.38"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13189"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.24270"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00065-2"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000797"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.1340011"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-07015-2"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00080"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12382"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10071488"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10083-0938"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12101"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031806"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051076"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1995.tb01249.x"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.5.2319-2326.1999"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1990.tb00914.x"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01753.x"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1306396"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12112599"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10020061"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12423"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13521"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13093"},{"key":"e_1_2_13_25_2","first-page":"352","article-title":"Matrix Metalloproteinases in Periodontal Tissue Remodelling","volume":"1","author":"Sodek J.","year":"1992","journal-title":"Matrix (Stuttgart, Germany) Supplement"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15061630"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12999"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.14189"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2022.03.005"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/10732748251351419"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12010058"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090374"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01114.x"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.3390\/bios10050044"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10080562"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14008"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0721"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10100838"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13050903"},{"key":"e_1_2_13_40_2","first-page":"167","article-title":"Diagnostic Discrimination of Bleeding On Probing During Maintenance Periodontal Therapy","volume":"3","author":"Chaves E. S.","year":"1990","journal-title":"American Journal of Dentistry"},{"key":"e_1_2_13_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0006"},{"key":"e_1_2_13_42_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.6.347"},{"key":"e_1_2_13_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19-0557"},{"key":"e_1_2_13_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-024-05678-3"},{"key":"e_1_2_13_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00319.x"},{"key":"e_1_2_13_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/1878-5085-4-16"},{"key":"e_1_2_13_47_2","doi-asserted-by":"publisher","DOI":"10.34172\/joddd.40958"},{"key":"e_1_2_13_48_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140421"},{"key":"e_1_2_13_49_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10030395"},{"key":"e_1_2_13_50_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.50.31504"},{"key":"e_1_2_13_51_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.291102.x"},{"key":"e_1_2_13_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"},{"key":"e_1_2_13_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13253"},{"key":"e_1_2_13_54_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.00677.x"},{"key":"e_1_2_13_55_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25179421"},{"key":"e_1_2_13_56_2","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2020\/43031.13467"},{"key":"e_1_2_13_57_2","first-page":"7","article-title":"Der Pr\u00e4ventionsbegriff in der Parodontologie [The Concept of Prevention in Periodontology]","volume":"31","author":"Jordan A. R.","year":"2020","journal-title":"Parodontologie"},{"key":"e_1_2_13_58_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130156"},{"key":"e_1_2_13_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12568"},{"key":"e_1_2_13_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01603.x"},{"key":"e_1_2_13_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1980.tb01963.x"},{"key":"e_1_2_13_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2008.tb00207.x"},{"key":"e_1_2_13_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2016.58"},{"key":"e_1_2_13_64_2","doi-asserted-by":"publisher","DOI":"10.4317\/jced.59752"},{"key":"e_1_2_13_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13204"},{"key":"e_1_2_13_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-013-9486-6"},{"key":"e_1_2_13_67_2","doi-asserted-by":"publisher","DOI":"10.1080\/17437199.2016.1151372"},{"key":"e_1_2_13_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2000.tb00580.x"},{"key":"e_1_2_13_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/apps.12176"},{"key":"e_1_2_13_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordhb\/9780195399820.013.0003"},{"key":"e_1_2_13_71_2","volume-title":"Health Psychology: Revisiting the Classic Studies","author":"Mansell W.","year":"2024"},{"key":"e_1_2_13_72_2","doi-asserted-by":"publisher","DOI":"10.1177\/0963721417754199"},{"key":"e_1_2_13_73_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7234.526"},{"key":"e_1_2_13_74_2","first-page":"24","article-title":"A Proposed Client Self-Care Commitment Model","volume":"74","author":"Calley K. H.","year":"2000","journal-title":"Journal of Dental Hygiene: JDH"},{"key":"e_1_2_13_75_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5037.2006.00175.x"},{"key":"e_1_2_13_76_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.119.2.254"},{"key":"e_1_2_13_77_2","doi-asserted-by":"publisher","DOI":"10.1017\/9781108677318.009"},{"key":"e_1_2_13_78_2","doi-asserted-by":"publisher","DOI":"10.1017\/9781108677318.037"},{"key":"e_1_2_13_79_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2098-1"}],"container-title":["International Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ijod\/4285673","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/ijod\/4285673","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ijod\/4285673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:30:46Z","timestamp":1773009046000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/ijod\/4285673"}},"subtitle":[],"editor":[{"given":"Roberta","family":"Gasparro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/ijod\/4285673"],"URL":"https:\/\/doi.org\/10.1155\/ijod\/4285673","archive":["Portico"],"relation":{},"ISSN":["1687-8728","1687-8736"],"issn-type":[{"value":"1687-8728","type":"print"},{"value":"1687-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4285673"}}