{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T10:07:42Z","timestamp":1779012462257,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":131,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Dental caries is the most prevalent dental disease, especially in childhood, involved in a dynamic pathological process, rendering a microbial shift towards survival and overgrowth of acidogenic and aciduric bacterial species, in which the interaction of biofilm and exposure to carbohydrates is directly associated with lesion formation. The objective of this study was to compare the efficacy of a dentifrice containing 0.8%\n                    <jats:italic>Lippia sidoides<\/jats:italic>\n                    Cham oil (LSO) against\n                    <jats:italic>Streptococcus mutans<\/jats:italic>\n                    (\n                    <jats:italic>S. mutans<\/jats:italic>\n                    ) in children. This was a randomized and controlled study. Forty participants, aged between 6 and 12\u2009years, of both sexes, with the presence of at least one carious lesion, were recruited to participate in the study. Participants were randomly assigned into two different groups. The first group (G1) received topical treatment with 0.8% LSO dentifrice, and the control received fluoridated common dentifrice (G2), for brushing their teeth for 1\u2009min thrice a day. Saliva was collected at seven different times: the baseline (D0), after 5 days (D5), 15 days (D15), 30 days (D30), 60 days (D60), 180 days (D180), and after 1\u2009year\/365 days (D365). The LSO dentifrice group showed a significant reduction in\n                    <jats:italic>S. mutans<\/jats:italic>\n                    levels at day 30 compared with baseline (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009 &lt; 0.05), and this reduction was maintained at days 60, 180, and 365. In contrast, the control group demonstrated a temporary reduction at day 30, with bacterial levels returning to baseline by day 365. Intergroup comparisons revealed significantly lower\n                    <jats:italic>S. mutans<\/jats:italic>\n                    counts in the LSO group from day 30 onward, with differences persisting through 1\u2009year (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009 &lt; 0.05). The LSO dentifrice 0.8%, when used thrice daily for 30 days, showed a greater reduction in\n                    <jats:italic>S. mutans<\/jats:italic>\n                    for up to 360 days when compared to common fluoride dentifrice in children with caries.\n                  <\/jats:p>","DOI":"10.1155\/ijod\/4772820","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:38:29Z","timestamp":1778578709000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of\n                    <i>Lippia sidoides<\/i>\n                    Containing\u2010Dentifrice in Children With Dental Caries: A Clinical Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2975-2244","authenticated-orcid":false,"given":"Patr\u00edcia Leal Dantas","family":"Lobo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4197-6002","authenticated-orcid":false,"given":"Cristiane S\u00e1 Roriz","family":"Fonteles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3568-3089","authenticated-orcid":false,"given":"L\u00eddia Audrey Rocha","family":"Valadas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8183-4960","authenticated-orcid":false,"given":"Said Gon\u00e7alves da Cruz","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8893-5323","authenticated-orcid":false,"given":"Francisco Vagnaldo","family":"Fechine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6826-8930","authenticated-orcid":false,"given":"Maria Elisabete Amaral de","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12682"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2018.12.004"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20176661"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.30"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-016-1905-5"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/1872208313666190826145453"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6647849"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8532701"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-05722013000100005"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-77572009000500010"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.10.018"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2014.04.021"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20047329"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000487815"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-020-01842-6"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/08927014.2021.1885649"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1554-6947"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/08927014.2024.2332709"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13112585"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512449463"},{"key":"e_1_2_13_21_2","first-page":"437","article-title":"Effect of a Dentifrice Containing Triclosan, Cetylpyridinium Chloride, and Essential Oils on Gingival Status in Schoolchildren: A Randomized Clinical Pilot Study","volume":"46","author":"Cagetti M. G.","year":"2015","journal-title":"Quintessence International"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201902164"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13568-017-0344-y"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.5530\/jyp.2019.11.86"},{"key":"e_1_2_13_25_2","first-page":"28","article-title":"Clinical Effect of a Gel Containing Lippia Sidoides on Plaque and Gingivitis Control","volume":"7","author":"Pereira S. 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