{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:51:10Z","timestamp":1791355870827,"version":"4.3.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":278,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This in vitro study investigated whether therapeutic radiation and the timing of radiotherapy in relation to endodontic treatment influence the dislodgment resistance of four commonly used root canal sealers bonded to radicular dentin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventy\u2010two extracted human single\u2010rooted teeth were standardized and allocated into four experimental groups according to the sealer used: AH Plus, Cerafill RCS, Sealapex, and Tubliseal. Each group was further divided into three subgroups based on the irradiation protocol: nonirradiated control, root canal treatment followed by radiotherapy, and radiotherapy followed by root canal treatment. Irradiated specimens received a cumulative dose of 70\u2009Gy using a medical linear accelerator. Root canals were instrumented with the ProTaper rotary system and obturated using a single\u2010cone technique with the assigned sealer. Following specimen preparation, push\u2010out bond strength (PBS) was measured using a universal testing machine, and the mode of bond failure was evaluated under stereomicroscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AH Plus demonstrated the highest PBS across all experimental conditions, followed by Cerafill RCS, whereas Sealapex and Tubliseal exhibited comparatively lower values. Exposure to therapeutic radiation produced a modest reduction in bond strength; however, neither radiation nor the sequence of radiotherapy and endodontic treatment resulted in statistically significant differences within individual sealer groups. Failure mode analysis showed a predominance of cohesive and mixed failures, with no significant differences among the irradiation protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Within the limitations of this in vitro investigation, therapeutic radiation had only a limited influence on the adhesion of the evaluated root canal sealers to radicular dentin, and the timing of radiotherapy relative to root canal treatment did not significantly affect dislodgment resistance. AH Plus consistently demonstrated superior bonding performance under both irradiated and nonirradiated conditions, indicating its potential suitability for endodontic treatment in patients undergoing head and neck radiotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijod\/5302801","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:08:37Z","timestamp":1791353317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of Therapeutic Radiation and Treatment Timing on Dislodgment Resistance of Four Root Canal Sealers: An In Vitro Push\u2010Out Bond Strength Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3749-855X","authenticated-orcid":false,"given":"Emshal","family":"Malik","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Manipal College of Dental Sciences Mangalore Manipal Academy of Higher Education  Manipal India  manipal.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3975-040X","authenticated-orcid":false,"given":"Laxmish","family":"Mallya","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Manipal College of Dental Sciences Mangalore Manipal Academy of Higher Education  Manipal India  manipal.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4691-9728","authenticated-orcid":false,"given":"M. S.","family":"Athiyamaan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Kasturba Medical College Mangalore Manipal Academy of Higher Education  Manipal India  manipal.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9222-863X","authenticated-orcid":false,"given":"Dilson","family":"Lobo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Kasturba Medical College Mangalore Manipal Academy of Higher Education  Manipal India  manipal.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4159-1233","authenticated-orcid":false,"given":"M.","family":"Roma","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Manipal College of Dental Sciences Mangalore Manipal Academy of Higher Education  Manipal India  manipal.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-4029","authenticated-orcid":false,"given":"Karthik","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Manipal College of Dental Sciences Mangalore Manipal Academy of Higher Education  Manipal India  manipal.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4607-895X","authenticated-orcid":false,"given":"K.","family":"Jayaprakash","sequence":"additional","affiliation":[{"name":"Department of Dental Materials Biomaterials and Research Centre Yenepoya Dental College Yenepoya (Deemed to be University)  Mangalore India  yenepoya.edu.in"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2021.42.3.20210660"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-019-1208-1"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1221"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2011.03.003"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-05029-4"},{"key":"e_1_2_14_6_2","doi-asserted-by":"crossref","DOI":"10.3390\/app13179755","volume-title":"Clinical Approaches to the Three-Dimensional Endodontic Obturation Protocol for Teeth With Periapical Bone Lesions","author":"Gusiyska A.","year":"2023"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.2019-288"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.5395\/rde.2021.46.e22"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/jcd.jcd_303_23"},{"key":"e_1_2_14_10_2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.4103\/ccd.ccd_640_18","article-title":"Comparison of Push-Out Bond Strength of Three Different Obturating Systems to Intraradicular Dentin: An in Vitro Study","volume":"10","author":"Moinuddin M.","year":"2019","journal-title":"Contemporary Clinical Dentistry"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2009.0162"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2014.05.011"},{"key":"e_1_2_14_13_2","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/iej.12556","article-title":"Influence of Therapeutic Cancer Radiation on the Bond Strength of an Epoxy- or an MTA-Based Sealer to Root Dentine","volume":"49","author":"Martins C. 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