{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:12:21Z","timestamp":1777403541027,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":209,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The split\u2010mouth randomized clinical trial evaluated and compared the clinical efficacy and patient\u2010centered outcomes of platelet\u2010rich fibrin (PRF) combined with modified coronally advanced flap (MCAF) and minimally invasive coronally advanced flap (MICAF) techniques for the treatment of multiple adjacent gingival recession (GR) Cairo\u2019s RT1\u2009and\/or RT2.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Eighteen participants with multiple GR defects were treated using MCAF\u2009+\u2009PRF and MICAF\u2009+\u2009PRF approaches in a split\u2010mouth design. A qualified periodontist examined the periodontal clinical parameters (recession height [RH] recession width [RW], clinical attachment level [CAL] gain, probing depth [PD], keratinized tissue width [KTW], and gingival thickness [GT]) and aesthetics at baseline and 6 months later. After 7 days, 3 months, and 6 months, patient\u2010centered outcomes relating to pain\/discomfort and aesthetics were evaluated using a visual analog scale (VAS) and a questionnaire. A statistical study was performed on the variations between the original recording and the subsequent months.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Both the surgical methods showed statistically significant improvements in all clinical parameters, such as RH, RW, CAL, PD, and KTW (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). MICAF\u2009+\u2009PRF was found to have a similar clinical efficacy to MCAF\u2009+\u2009PRF for tissue gain; yet between\u2010group differences in GT after 6 months were not statistically significant. Patient\u2010related outcome measures (PROMs) were significantly better in MICAF\u2009+\u2009PRF with lower VAS pain scores (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) and higher ratings of esthetic satisfaction (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) at 6 months\u2019 follow\u2010up.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    Name of the Registry: Clinical Trials Registry \u2010 India (CTRI); Registration Number: CTRI\/2019\/01\/016994\n                  <\/jats:p>","DOI":"10.1155\/ijod\/5585609","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T05:20:51Z","timestamp":1753852851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Platelet\u2010Rich Fibrin in Treatment of Multiple Adjacent Gingival Recession Defects Using Minimally Invasive Coronally Advanced Flap and Modified Coronally Advanced Flap: A Split\u2010Mouth Randomized Controlled Trial"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2022-7830","authenticated-orcid":false,"given":"Vandana","family":"Daga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6943-5761","authenticated-orcid":false,"given":"Ashita","family":"Uppoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5980-2698","authenticated-orcid":false,"given":"Sangeeta Umesh","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0736-3750","authenticated-orcid":false,"given":"Priyanka 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