{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T12:21:13Z","timestamp":1787574073957,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":235,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This exploratory study investigated the associations between cannabis use, methylphenidate (MPH) exposure, demographic factors, and radiographically detected pulp stones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective case\u2010control study was conducted to analyze the records of 200 adults (100 with pulp stones and 100 controls) treated at a university dental clinic (2020\u20132023). The variables included age, sex, cannabis use, MPH use, tobacco smoking, and clenching\/grinding behaviors. Analyses included Fisher\u2019s exact test, Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test, and multivariable logistic regression with Benjamini\u2013Hochberg (BH) correction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cannabis use showed the strongest independent association with radiographic pulp stones (OR\u2009=\u20096.54, 95% CI: 1.95\u201321.95; BH\u2010corrected\n                      <jats:italic>p<\/jats:italic>\n                      = 0.012). Age was also independently associated (OR\u2009=\u20091.08\/year; BH\u2010corrected\n                      <jats:italic>p<\/jats:italic>\n                      = 0.035). MPH use was associated with pulp stones on unadjusted analysis (OR\u2009=\u20092.3,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.042), but not after adjustment (OR\u2009=\u20091.72; BH\u2010corrected\n                      <jats:italic>p<\/jats:italic>\n                      = 0.232). MPH users demonstrated significantly higher rates of documented clenching\/grinding behaviors than nonusers (41.7% vs. 23.8%;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.038). Tobacco smoking was not associated with the presence of pulp stones.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cannabis use was the strongest independent factor associated with radiographically detected pulp stones. MPH users showed higher rates of clenching\/grinding behaviors, supporting a possible mechanistic relationship between psychostimulant exposure and parafunctional activity. The findings should be considered exploratory and hypothesis\u2010generating.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>Pulp stones may be radiographic indicators of underlying parafunctional activity and behavioral risk factors, supporting more comprehensive dental history\u2010taking and monitoring strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijod\/5655140","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:21:13Z","timestamp":1787570473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between Cannabis Use, Methylphenidate Exposure, and Radiographically Detected Pulp Stones: An Exploratory Case\u2010Control Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6858-3335","authenticated-orcid":false,"given":"Michael","family":"Saminsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliya","family":"Ben-David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenia","family":"Balaban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0642-0028","authenticated-orcid":false,"given":"Iris","family":"Manor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8173-5804","authenticated-orcid":false,"given":"Tomer","family":"Goldberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.10.015"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/japtr.japtr_126_22"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2008.01374.x"},{"key":"e_1_2_13_4_2","volume-title":"Ten Cate\u2019s Oral Histology","author":"Nanci A.","year":"2024"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.29309\/TPMJ\/18.3756"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17249293"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.45484"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-025-06492-3"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/617590"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2008.01853.x"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(71)90330-6"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.52037\/eads.2023.0001"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192215261"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.12.005"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11247453"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/odi.15270"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2023.2451"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/17571472.2010.11493296"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-022-00392-2"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52205-6"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-05946-0"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13662"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12633"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2008.01881.x"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2018.0114"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.58240\/1829006X-2025.1-96"},{"key":"e_1_2_13_27_2","volume-title":"Management of Temporomandibular Disorders and Occlusion","author":"Okeson J. 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