{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:55:46Z","timestamp":1780988146127,"version":"3.54.1"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    Noncontained (1\u2010 or combined 1\u2010 to 2\u2010wall) periodontal intraosseous defects represent challenging clinical situations with unpredictable surgical therapeutic outcomes. This randomized clinical trial assessed demineralized freeze\u2010dried bone allograft (DFDBA) with low speed\u2010platelet\u2010rich fibrin (PRF) membrane compared to DFDBA with collagen membrane (CM) in the surgical periodontal therapy of noncontained intraosseous defects of stage III periodontitis patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methodology:<\/jats:bold>\n                    Twenty\u2010two stage III periodontitis patients with noncontained intraosseous defects measuring \u22653\u2009mm and clinical attachment loss \u22655\u2009mm were randomly allocated into two groups: test group (low\u2010speed PRF membrane\u2009+\u2009DFDBA) and control group (CM\u2009+\u2009DFDBA), with 11 participants per group. Clinical and radiographic assessments were conducted at baseline, 3, 6, 9, and 12 months for clinical attachment level (CAL; primary outcome), gingival recession depth (GRD), probing depth (PD), full mouth bleeding score (FMBS) and full mouth plaque score (FMPS), radiographic bone fill and radiographic linear defect depth (RLDD; all secondary outcomes).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The mean (\u00b1SD) CAL\u2010gain for the test group was 2.45 (\u00b11.51), 2.91 (\u00b11.70), 2.91 (\u00b11.87), and 2.82 (\u00b11.83) mm, while for the control group 2.82 (\u00b11.25), 3.27 (\u00b11.27), 3.00 (\u00b11.41), and 2.64 (\u00b11.50) mm at 3, 6, 9, and 12 months, respectively, with no significant intergroup differences (\n                    <jats:italic>p<\/jats:italic>\n                    &gt; 0.05). Despite the absence of significant intergroup differences, both groups demonstrated significant intragroup improvement in CAL\u2010 and PD\u2010gain, and RLDD\u2010reduction at 3, 6, 9, and 12 months as well as RLDD improvement at 12 months (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    PRF membranes, in conjunction with DFDBA, show significant improvement of periodontal clinical and radiographic parameters, comparable to CMs with DFDBA.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    ClinicalTrials.gov identifier: NCT03922503\n                  <\/jats:p>","DOI":"10.1155\/ijod\/6393105","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T23:36:08Z","timestamp":1740526568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Low\u2010Speed Platelet\u2010Rich Fibrin Membrane in Conjunction With Demineralized Freeze\u2010Dried Bone Allograft (DFDBA) Compared to Collagen Membrane With DFDBA in Noncontained Intraosseous Defects of Stage III Periodontitis: A Randomized Controlled Clinical Trial"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4024-6469","authenticated-orcid":false,"given":"Najeeb","family":"Almoliky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"Hosny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weam","family":"Elbattawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-3609","authenticated-orcid":false,"given":"Karim","family":"Fawzy El-Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,23]]},"reference":[{"key":"e_1_2_13_1_2","volume-title":"StatPearls [Internet]","author":"Torabi S.","year":"2022"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054599"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12008"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.1.3"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12048"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13259"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12513"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.38931"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000003396"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.008"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000009450"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-024-06128-w"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-017-0785-7"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160443"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36734"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/09500693.2011.565088"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-022-04627-2"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14372"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13344"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2015.1035672"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.145803"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-04954-y"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma15010254"},{"key":"e_1_2_13_24_2","first-page":"1","article-title":"Autogenous Platelet Concentrates for Treatment of Intrabony Defects\u2014A Systematic Review With Meta-Analysis","author":"Miron R. 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