{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:51:12Z","timestamp":1781855472256,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":168,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The current trial aimed to assess the effects of phase I periodontal therapy on gingival crevicular fluid (GCF) adiponectin and resistin levels in obese individuals with varying stages and grades of periodontitis. The feasibility of using adiponectin and resistin in a periodontitis staging and grading classification system was being evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This prospective clinical study was carried out on 60 class \u2162 obese periodontitis patients who were divided equally into group \u0406, first stage, grade B periodontitis; group \u2161, second stage, grade B periodontitis; group \u2162, third stage, grade B periodontitis; and group \u2163, fourth stage, grade C periodontitis. Body mass index (BMI), HbA1c, and periodontal indices were assessed, and GCF was collected and analyzed for adiponectin and resistin, before and 3 months after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A positive correlation was observed between BMI\/HbA1c and periodontal disease stages. After periodontal therapy, adiponectin and resistin levels were obviously affected. In group \u2162 resistin decreases from 25.68\u2009\u00b1\u20090.89 to 14.68\u2009\u00b1\u20091.54\u2009ng\/mL, adiponectin rose from 155.8\u2009\u00b1\u200939.7 to 435.8\u2009\u00b1\u200949.2\u2009ng\/mL. In group \u2163, resistin decreased from 53.2\u2009\u00b1\u20091.1 to 20.3\u2009\u00b1\u20092.03\u2009ng\/mL, and adiponectin increased from 104.41\u2009\u00b1\u20098.87 to 543.21\u2009\u00b1\u200936.81\u2009ng\/mL. There were no statistically significant correlations between clinical attachment level (CAL) and adiponectin\/resistin. In grade B periodontitis, resistin decreased from 17.25\u2009\u00b1\u20096.1 to 13.5\u2009\u00b1\u20091.39\u2009ng\/mL after periodontal therapy. Adiponectin rose from 257.27\u2009\u00b1\u200984.26 to 355.61\u2009\u00b1\u200972.4\u2009ng\/mL. In grade C periodontitis, resistin expression was lower, from 53.2\u2009\u00b1\u20091.1 to 20.37\u2009\u00b1\u20092.03\u2009ng\/mL, whereas adiponectin was elevated from 104.41\u2009\u00b1\u20098.8 to 543.21\u2009\u00b1\u200936.81\u2009ng\/mL after 3 months of periodontal control treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adiponectin and resistin were significantly affected after periodontal therapy, especially in stage 3 and stage 4 periodontitis. Adiponectin can be used as an intermediary for periodontitis grading.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijod\/6645532","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:57:16Z","timestamp":1781852236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of GCF Adiponectin and Resistin Expression Level as an Indicator in Periodontal Staging and Grading After Periodontal Therapy in Class III Obese Patients"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9073-0451","authenticated-orcid":false,"given":"Bahaa Mohammed","family":"Badr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8041-2706","authenticated-orcid":false,"given":"Ibrahim Hammad","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8514-210X","authenticated-orcid":false,"given":"Abdullah Ibrahim","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5765-4580","authenticated-orcid":false,"given":"Shuaibu Abdullahi","family":"Hudu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2933-8614","authenticated-orcid":false,"given":"Asmaa Rashad","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0136-8520","authenticated-orcid":false,"given":"Asem Mohammed","family":"Kamel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12344"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40496-022-00323-y"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/jioh.jioh_108_24"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_283_20"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-021-01559-z"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2018.0102"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjw011"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.61.01.072"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12070"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.05.014"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12457"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.05.025"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0721"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12670"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12239"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12417"},{"key":"e_1_2_14_17_2","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13133856","article-title":"Class 3 Obesity and Oral Health in Adults: A Scoping Review of the Challenges for Oral Healthcare Services","volume":"13","author":"Malik Z.","year":"2024","journal-title":"Journal of Clinical Medicine"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.4103\/ccd.ccd_1_18"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2010.00808.x"},{"key":"e_1_2_14_20_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152187","article-title":"Body Mass Index, Smoking and Hypertensive Disorders During Pregnancy: A Population-Based Case-Control Study","volume":"11","author":"Gudnad\u00f3ttir T. 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