{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:36:33Z","timestamp":1773005793424,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"vor","delay-in-days":277,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Incipient enamel caries, known as white spot lesions (WSLs), can be prevented or halted with proper oral hygiene, diet control, and application of remineralizing agents such as silver diamine fluoride (SDF); however, dark staining is a major drawback of SDF. This study aimed to compare the effects of at\u2010home and in\u2010office bleaching on SDF\u2010induced staining of WSLs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In this in vitro study, 44 bovine central incisors were randomly assigned to 2 groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922) for artificial induction of superficial and deep WSLs. Next, both groups underwent remineralization by using 38% SDF for 1\u2009min, rinsed, and stored in artificial saliva. After 1 week, each group was randomly divided into two subgroups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911) to undergo at\u2010home bleaching and in\u2010office bleaching. The , , and  color parameters of all specimens were measured at 4 time points of baseline (sound enamel), after demineralization, after SDF remineralization, and after bleaching, and the color change (\u0394\n                      <jats:italic>E<\/jats:italic>\n                      <jats:sub>00<\/jats:sub>\n                      ) was calculated. Data were analyzed by one\u2010way and two\u2010way ANOVA and Sidak\u2010adjusted post hoc test (\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Lesion depth did not significantly affect early\u2010stage discoloration (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 &gt; 0.05). However, a significant interaction was found between lesion depth and bleaching type at later stages (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 &lt; 0.001). In\u2010office bleaching significantly improved \u0394\n                      <jats:italic>E<\/jats:italic>\n                      <jats:sub>00<\/jats:sub>\n                      compared to at\u2010home bleaching but only in superficial lesions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both at\u2010home and in\u2010office bleaching can lighten dark lesions caused by SDF after remineralization, although they may not fully restore tooth color to normal. In\u2010office bleaching led to significantly greater color improvement than at\u2010home bleaching in superficial lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijod\/6837096","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T05:57:17Z","timestamp":1759730237000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Effects of At\u2010Home and In\u2010Office Bleaching on Discoloration Due to Treatment of White Spot Lesions With Silver Diamine Fluoride"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9837-9642","authenticated-orcid":false,"given":"Farzaneh","family":"Shirani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leili","family":"Mirmiran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8985-4300","authenticated-orcid":false,"given":"Abolfazl","family":"Mirmiran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,5]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517740124"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2018.08.011"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.2018-008"},{"key":"e_1_2_10_4_2","first-page":"169","article-title":"Tooth Whitening: Efficacy, Effects and Biological Safety","volume":"33","author":"Craig B.","year":"1999","journal-title":"Probe-Ottawa"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.67275"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.68498"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2024.105353"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/9780203417430"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jebdp.2014.02.006"},{"key":"e_1_2_10_10_2","first-page":"503","article-title":"Use of Different Concentrations of Carbamide Peroxide for Bleaching Teeth: An in Vitro Study","volume":"29","author":"Leonard R. 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