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In trained groups, animals performed moderate\u2010intensity aerobic training (treadmill) for 11 weeks. The maximal capacity test (\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      ) was performed at baseline (0 weeks), 8 and 11 weeks to analyse physical capacity and increase training velocity to maintain training intensity. In the AP\u2010induced groups, coronal access of the left maxillary and mandibular first and second molars was performed after 8 weeks of training, and the pulp chamber was kept open for 21 days. After euthanasia, the hemi\u2010mandible was submitted to histopathological, radiographical and micro\u2010computed tomography (micro\u2010CT) analyses to evaluate the inflammation, the area and the volume of periapical bone resorption, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      results of trained groups were higher than those of sedentary groups (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). There was no difference in\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      results between trained groups (Ex and Ex\u2010AP;\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05), or between sedentary groups (S and S\u2010AP) (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05). Regarding volume and area of apical bone resorption, there was no difference between S\u2010AP and Ex\u2010AP (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05). Histopathological qualitative analysis also showed no differences between S\u2010AP and Ex\u2010AP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Physical exercise did not influence AP development, nor did AP affect physical exercise capacity in trained rats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijod\/7317709","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T07:27:21Z","timestamp":1767425241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interrelationship Between Physical Exercise and Apical Periodontitis in Trained 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