{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:41:00Z","timestamp":1773006060161,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":300,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Genetics plays a crucial role in determining individual susceptibility to dental caries. Certain\n                      <jats:italic>beta-defensin 1<\/jats:italic>\n                      (\n                      <jats:italic>DEFB1<\/jats:italic>\n                      ) gene variants may be linked to oral diseases. One of the most prevalent problems with oral health is dental caries. Between 60% and 90% of schoolchildren and the vast majority of adults suffer from dental caries. This study aimed to examine the genetic association between the\n                      <jats:italic>DEFB1<\/jats:italic>\n                      gene variants rs11362 and rs1799946 and dental caries in a case\u2013control study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study included 202 participants, of whom 119 demonstrated high dental caries, while 83 acted as controls with low dental caries. Most of them were referred to the Medical University\u2019s Dental Clinic in Shiraz, Iran. Following the acquisition of written and informed consent, genomic DNA was extracted from peripheral blood. Tetra\u2010primer ARMS\u2013PCR was employed to identify the\n                      <jats:italic>DEFB1<\/jats:italic>\n                      promoter region polymorphisms rs11362 and rs1799946.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Allelic, genotypic, and haplotypes frequencies did not differ between the case and control groups, according to the genotyping results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      To find the dental caries\u2010vulnerable loci in our case and control groups, more studies with a bigger sample size are essential. Furthermore, functional research is necessary to elucidate how these variations affect\n                      <jats:italic>DEFB1<\/jats:italic>\n                      expression.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijod\/8465309","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T21:43:14Z","timestamp":1761687794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Genetic Variants in\n                    <i>DEFB1<\/i>\n                    Gene and Dental Caries Susceptibility"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5066-9632","authenticated-orcid":false,"given":"Mohammad 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