{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:21:04Z","timestamp":1788301264273,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Periodontitis is a chronic immunoinflammatory disease involving various components that affect the tissues surrounding the tooth. The host immune response to the presence of periodontopathogenic microorganisms activates several cytokine systems involved in alveolar bone resorption in periodontitis; among them is the receptor activator of nuclear factor\u2010\u03baB (RANK)\/receptor activator of nuclear factor\u2010\u03baB ligand (RANKL) system, which depends on the interleukin (IL)\u201023\/IL\u201017 axis. There is a tendency toward increased IL\u201023, IL\u201017, and IL\u201017 receptor (IL\u201017RA) and a discrepancy in IL\u201023 receptor (IL\u201023R) in gingival tissue (GT) of patients with periodontitis. Therefore, the aim of this study was to quantify the expression of the IL\u201023\/IL\u201017A axis using the western blotting (WB) technique in GT samples from patients with periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study included 49 subjects: 25 healthy subjects and 24 subjects with periodontitis. GT samples were collected during periodontal surgery. WB was used to evaluate the levels of IL\u201023, IL\u201017A, IL\u201023R, and IL\u201017RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found a significant increase in IL\u201023, IL\u201017A, IL\u201023R, and IL\u201017RA protein levels in the periodontitis group compared with the healthy group; we also detected bands with unexpected molecular weights for both receptors. Moreover, we found a significant positive correlation between IL\u201023 and IL\u201017A with both receptors, while IL\u201023, IL\u201017A, IL\u201023R, and IL\u201017RA correlated positively with two periodontal clinical parameters, namely the clinical attachment level and the percentage of radiographic bone loss (%RBL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, we detected overexpression of IL\u201023, IL\u201017A, and their receptors in GT of patients with periodontitis, confirming that the IL\u201023\/IL\u201017A axis is involved in periodontal disease.<\/jats:p>\n                  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