{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:58:28Z","timestamp":1790607508692,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":270,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Zinc citrate trihydrate (ZCT) has antibacterial and anti\u2010inflammatory properties and is widely used in oral\u2010care products. However, evidence regarding its effectiveness in orthodontic patients remains limited. This study aimed to evaluate the effects of a toothpaste containing 2% ZCT on gingival inflammation, plaque accumulation, and plaque\u2010associated bacterial load in patients wearing fixed orthodontic appliances.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized controlled clinical trial was conducted among 102 patients with plaque\u2010induced gingivitis undergoing fixed orthodontic treatment. Participants were randomly assigned to use either a toothpaste containing 2% ZCT (test group) or a conventional toothpaste without ZCT (control group). The gingival index (GI) and Modified Quigley\u2013Hein Plaque Index (MQHPI) were recorded at baseline, after 1 week, and after 4 weeks. Supragingival plaque samples were collected at baseline and after 4 weeks and analyzed using real\u2010time polymerase chain reaction to quantify selected plaque\u2010associated bacterial species. Linear mixed\u2010effects models were used to evaluate the effects of time, treatment, and their interaction on GI and MQHPI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Exploratory time\u2010specific comparisons at 4 weeks showed lower GI and MQHPI and lower loads of\n                      <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                      (Fn),\n                      <jats:italic>Tannerella forsythia<\/jats:italic>\n                      (Tf), and\n                      <jats:italic>Solobacterium moorei<\/jats:italic>\n                      (Sm) in the ZCT group. However, the longitudinal mixed\u2010effects analyses showed no significant treatment\u2010by\u2010time interaction for either the clinical outcomes or the quantitatively assessable bacterial species.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both groups showed clinical improvement over time. However, the longitudinal analyses did not demonstrate an additional clinical or microbiological effect attributable to the 2% ZCT toothpaste during the 4\u2010week study period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijod\/9264740","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:25:31Z","timestamp":1790605531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adjunctive Effects of a 2% Zinc Citrate Toothpaste on Plaque and Oral Microbiota in Orthodontic Patients: A Randomized Controlled Trial"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0057-7972","authenticated-orcid":false,"given":"Thi Thanh Ngoc","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2191-8293","authenticated-orcid":false,"given":"Trung Chanh","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1470-8301","authenticated-orcid":false,"given":"Nguyen Quan","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tin Hien","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9138-4510","authenticated-orcid":false,"given":"Thi Quynh Lan","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(94)70097-4"},{"key":"e_1_2_13_3_2","article-title":"Prevalence of Caries and Gingivitis in Patients Undergoing Orthodontic Treatment","volume":"45","author":"Dhole R. I.","year":"2024","journal-title":"Journal of Advanced Zoology"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.19070\/2377-8075-20000243"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-6-S1-S14"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb02316.x"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2003.tb00913.x"},{"key":"e_1_2_13_8_2","unstructured":"Food and D. Administration Oral Health Care Drug Products for Over-the-Counter Human Use; Antigingivitis\/Antiplaque Drug Products; Establishment of a Monograph 2003 68 Federal Register."},{"key":"e_1_2_13_9_2","first-page":"127","article-title":"Dental Plaque Control Effect of a Zinc Citrate Dentifrice","volume":"19","author":"Barnes V. M.","year":"2008","journal-title":"The Journal of Clinical Dentistry"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-008-0227-3"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2003.tb00916.x"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.101778"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-014-1316-0"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1970.41.1.41"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.5114\/jos.2021.106571"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.59413"}],"container-title":["International Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ijod\/9264740","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/ijod\/9264740","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ijod\/9264740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:25:33Z","timestamp":1790605533000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/ijod\/9264740"}},"subtitle":[],"editor":[{"given":"Hannah","family":"Wesley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/ijod\/9264740"],"URL":"https:\/\/doi.org\/10.1155\/ijod\/9264740","archive":["Portico"],"relation":{},"ISSN":["1687-8728","1687-8736"],"issn-type":[{"value":"1687-8728","type":"print"},{"value":"1687-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9264740"}}