{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:52:46Z","timestamp":1789487566303,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":257,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Genomics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Medicinal and aromatic plants (MAPs) produce a remarkable diversity of specialized metabolites with significant pharmaceutical, nutraceutical, and industrial value. Although advances in long\u2010read sequencing, chromosome\u2010scale genome assembly, and pangenomics have greatly expanded genomic resources, the mechanistic links between genome architecture and phytochemical diversity remain incompletely understood. The present review synthesizes current evidence describing how structural genomic variation may contribute to phytochemical diversity, while acknowledging that many proposed genome\u2010to\u2010metabolite relationships require further experimental validation. Examples illustrate how genome architecture is associated with specialized\u2010metabolite biosynthesis through multiple regulatory processes. However, the strength of supporting evidence varies considerably among MAP species. Moreover, relatively few genome\u2010to\u2010metabolite relationships have been confirmed through direct functional validation. We further discuss how pangenomics, multiomics integration, genome editing, synthetic biology, and artificial intelligence support the discovery, validation, and engineering of specialized metabolic pathways. Casual conclusions are evaluated according to the strength of available evidence, highlighting where causal relationships have been experimentally established and where conclusions remain primarily association\u2010based. Overall, this review provides an integrated conceptual and evidence\u2010based perspective summarizing proposed relationships between genome architecture and phytochemical diversity and outlines future priorities for functional genomics, precision breeding, metabolic engineering, and sustainable utilization of MAPs.<\/jats:p>","DOI":"10.1155\/ijog\/2966459","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T14:51:42Z","timestamp":1789483902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanistic Perspectives From Genomics and Pangenomics of Medicinal and Aromatic Plants: Linking Genome Architecture to Phytochemical Diversity"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7852-6262","authenticated-orcid":false,"given":"Himanshu","family":"Saini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5639-1771","authenticated-orcid":false,"given":"Vishal","family":"Johar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalu","family":"Vyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0409-8642","authenticated-orcid":false,"given":"Vikrant","family":"Jaryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1653-2146","authenticated-orcid":false,"given":"Atin","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2672-1562","authenticated-orcid":false,"given":"Deepak","family":"Nanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2467-6326","authenticated-orcid":false,"given":"Anand","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4561-157X","authenticated-orcid":false,"given":"Jeevan Jyoti","family":"Kaushik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7494-9967","authenticated-orcid":false,"given":"Sahil","family":"Shamkuwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6446-9843","authenticated-orcid":false,"given":"Shubham","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_16_1_2","doi-asserted-by":"publisher","DOI":"10.26599\/FMH.2025.9420076"},{"key":"e_1_2_16_2_2","doi-asserted-by":"publisher","DOI":"10.26599\/FMH.2024.9420003"},{"key":"e_1_2_16_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57448-8"},{"key":"e_1_2_16_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2019.12.009"},{"key":"e_1_2_16_5_2","doi-asserted-by":"publisher","DOI":"10.3732\/ajb.1500320"},{"key":"e_1_2_16_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes16060636"},{"key":"e_1_2_16_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1252076"},{"key":"e_1_2_16_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.791219"},{"key":"e_1_2_16_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-arplant-090823-015358"},{"key":"e_1_2_16_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7652.2009.00459.x"},{"key":"e_1_2_16_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xplc.2023.100767"},{"key":"e_1_2_16_12_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.242594.118"},{"key":"e_1_2_16_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat4096"},{"key":"e_1_2_16_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065622"},{"key":"e_1_2_16_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2018.03.015"},{"key":"e_1_2_16_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2022.05.013"},{"key":"e_1_2_16_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.12926"},{"key":"e_1_2_16_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2024.1279738"},{"key":"e_1_2_16_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/hr\/uhad069"},{"key":"e_1_2_16_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-06255-8"},{"key":"e_1_2_16_21_2","volume-title":"Textbook of Forest Science","author":"Geetha K. 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