{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:13:17Z","timestamp":1788264797455,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":243,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Genomics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The crosstalk between inflammation and immunity plays a central role in tumor progression, immune evasion, and therapeutic response. Interleukin\u20101 receptor accessory protein (IL1RAP) is a key adaptor in inflammatory signaling, yet its immunological relevance and clinical implications in skin cutaneous melanoma (SKCM) remain largely unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed an integrative analysis combining pan\u2010cancer and melanoma\u2010focused datasets. Bulk transcriptomic, single\u2010cell, spatial transcriptomic, genomic alteration, pharmacogenomic, and clinical survival data were obtained from TCGA, GTEx, GEO, ENA, and other public resources. IL1RAP expression was evaluated across cancer types in relation to diagnostic performance, immune subtypes, survival outcomes, functional pathway activity, immune\u2013genomic states, somatic alterations, and drug\u2010response metrics. Melanoma\u2010focused analyses examined immune infiltration, methylation\u2010derived tumor\u2010infiltrating lymphocyte (MeTIL) scores, and exploratory survival associations in five treatment cohorts; the survival groups were defined using cohort\u2010specific optimal cutoffs rather than median splits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IL1RAP expression differed between tumor and normal tissues in multiple cancers, although the direction and magnitude varied by cancer type. Pan\u2010cancer survival associations were likewise context dependent. Single\u2010cell and spatial transcriptomic resources indicated cell\u2010type and spatial heterogeneity of IL1RAP expression within tumor microenvironments. Pathway, immune\u2013genomic, and pharmacogenomic analyses identified exploratory associations with functional states, genomic features, and drug\u2010response metrics. In SKCM, IL1RAP expression was associated with several immune\u2010infiltration estimates and higher MeTIL scores. Across five melanoma immunotherapy cohorts, the direction and magnitude of the overall survival associations varied substantially.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This retrospective integrative analysis suggests that IL1RAP may mark an inflammation\u2013immunity\u2013related state in SKCM. The heterogeneous associations across cancers and melanoma treatment cohorts support further validation but do not establish IL1RAP as a causal regulator, a treatment\u2010response predictor, or a therapeutic target.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijog\/3751729","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:18:40Z","timestamp":1788261520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["IL1RAP Is Associated With an Inflammation\u2013Immunity\u2013Related State in Skin Cutaneous Melanoma: Integrative Evidence From Pan\u2010Cancer Data and Melanoma Immunotherapy 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