{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:06:44Z","timestamp":1773025604905,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":265,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Genomics"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    The purpose of this study was to investigate the role of the ITGB1\/FAK\/AKT pathway in NRG\u20101 in mediating the axonal growth of dorsal root ganglion neurons in Type I diabetic rats and to explore the mechanism of neuronal axonal regeneration.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Result:<\/jats:bold>\n                    The effects of NRG\u20101 on neurite outgrowth in diabetic rats were determined by protein quantification and axon length analysis in which axons were identified with tubulin\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    III\u2010specific staining. Western blot showed that the signaling activity of the ITGB1\/FAK\/AKT pathway was decreased in diabetic rats compared with normal rats, and exogenous NRG\u20101 significantly promoted axonal growth and activated the pathway. After the addition of ITGB1\u2010specific siRNA, the axonal growth\u2013promoting effect of NRG\u20101 was partially reversed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    NRG\u20101 promotes axonal outgrowth in diabetic DRGs via upregulating the ITGB1\/FAK\/AKT pathway, providing a potential target for diabetic neuropathy.\n                  <\/jats:p>","DOI":"10.1155\/ijog\/5520810","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T10:01:59Z","timestamp":1758621719000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NRG\u20101 Promotes Axon Regeneration of Dorsal Root Ganglion Neurons in Diabetic Rats via ITGB1\/FAK\/AKT 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