{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:14:16Z","timestamp":1789805656941,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":261,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Genomics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multiple sclerosis (MS) is a neurodegenerative and inflammatory disease affecting gray and white matter in the brain. Due to the highly variable presentation of MS, making a reliable long\u2010term diagnosis based solely on initial clinical findings is extremely challenging. Long noncoding RNAs (lncRNAs) have been shown in recent research to have a role as prospective biomarkers that may offer data to forecast the onset and course of disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 100 healthy controls and 120 MS patients with 98 relapsing\u2010remitting (RR), 10 primary progressive (PP), and 12 secondary progressive (SP) cases were included in the blood sample collection. Gene expression was assessed with quantitative real\u2010time PCR. The receiver operating characteristic (ROC) curve analysis was employed to evaluate the potential for diagnostic analysis of lncRNA levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The expressions of IFNG\u2010AS1 and UCHL1\u2010AS1 were found to be significantly decreased (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001) in patients compared to the control group. After adjustment for age using ANCOVA, IFNG\u2010AS1 expression remained significantly lower in MS patients than in healthy controls (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001). IFNG\u2010AS1 may be considered a potential biomarker for MS diagnosis (AUC = 0.838).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IFNG\u2010AS1 demonstrates promising diagnostic potential for MS, whereas UCHL1\u2010AS1 shows only modest discriminatory value. However, these findings are preliminary and require further validation with functional studies to confirm clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijog\/7231094","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:48:18Z","timestamp":1789804098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Downregulation of IFNG\u2010AS1 and UCHL1\u2010AS1 in Peripheral Blood Cells of Multiple Sclerosis Patients: IFNG\u2010AS1 as a Candidate Diagnostic Biomarker"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5890-4462","authenticated-orcid":false,"given":"Ali","family":"Rajabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3752-1307","authenticated-orcid":false,"given":"Jeffrey D.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0489-6022","authenticated-orcid":false,"given":"Ali","family":"Samadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-022-03112-z"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2024.2362585"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s44197-025-00353-6"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517711568"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2018.08.008"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2022.102828"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-08182-7"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.187"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13081448"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23115877"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-017-0982-1"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20181335"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humgen.2025.201410"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-018-1508-1"},{"key":"e_1_2_13_15_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.retram.2021.103307","article-title":"IFNG-AS1 and MAF4 Long Non-Coding RNAs Are Upregulated in Acute Leukemia Patients Who Underwent Bone Marrow Transplantation","volume":"69","author":"Jafari L.","year":"2021","journal-title":"Current Research in Translational Medicine"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.1007347"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2019.10.012"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep17702"},{"key":"e_1_2_13_19_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.146672","article-title":"Increased Level of NEAT1 Long Non-Coding RNA Is Detectable in Peripheral Blood Cells of Patients With Parkinson\u2032s Disease","volume":"1730","author":"Boros F. 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