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This study shows that the BYHWT alcohol precipitation and 75% alcohol components can significantly reduce the serum levels of triglycerides (TGs), low\u2010density lipoprotein (LDL), cholesterol (CHO), and hepatic function damage indicators such as glutamic oxaloacetic transaminase (AST) and glutamic pyruvic transaminase (ALT) in hypercholesterolemia mouse model. After treatment, the presence of lipid droplets in liver cells was reduced, and the destruction of adipocytes was improved. The Western blot (WB) results showed that alcohol precipitation and 75% alcohol components can upregulate PPAR\n                    <jats:italic>\u03b3<\/jats:italic>\n                    , ABCA1, and LXR\n                    <jats:italic>\u03b1<\/jats:italic>\n                    . The expression of these components indicates that PPAR\n                    <jats:italic>\u03b3<\/jats:italic>\n                    upregulation can activate LXR\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , thus regulating the expression of ABCA1, mediating CHO efflux, promoting reverse cholesterol transport (RCT), and regulating the downstream gene CYP7A1 to participate in bile acid synthesis and metabolism. In summary, the experimental results indicate that the BYHWT alcohol precipitation, 50% alcohol, and 75% alcohol components can modulate the PPAR\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \/LXR\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \/ABCA1 pathway in hypercholesterolemia mouse model to promote CHO metabolism.\n                  <\/jats:p>","DOI":"10.1155\/ijog\/9595757","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T06:34:43Z","timestamp":1752129283000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Different Components of Buyang Huanwu Tang on the PPAR\n                    <i>\u03b3<\/i>\n                    \/LXR\n                    <i>\u03b1<\/i>\n                    \/ABCA1 Pathway in Hypercholesterolemia Mouse Model"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6402-7612","authenticated-orcid":false,"given":"Shuaihu","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3847-7994","authenticated-orcid":false,"given":"Yukun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5960-769X","authenticated-orcid":false,"given":"Xinxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6584-3062","authenticated-orcid":false,"given":"Xingtong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8027-221X","authenticated-orcid":false,"given":"Yuxue","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8298-0563","authenticated-orcid":false,"given":"Shijian","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruihong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4796-3480","authenticated-orcid":false,"given":"Jinbiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2773-4028","authenticated-orcid":false,"given":"Yunyue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0255-5125","authenticated-orcid":false,"given":"Xiao","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5927-7402","authenticated-orcid":false,"given":"Pengcheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2976-0092","authenticated-orcid":false,"given":"Hongbin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6105-9266","authenticated-orcid":false,"given":"Wenying","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.4103\/jehp.jehp_514_20"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.116110"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1087256"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2019-0053"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.22273"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i30.9295"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-020-01021-3"},{"key":"e_1_2_13_8_2","first-page":"1147","article-title":"Effect of Buyang Huanwu Decoction on Blood Lipid, HCY and Clinical Efficacy in Elderly Patients With Coronary Heart Disease Stable Angina Pectoris (QD and Blood Stasis Syndrome)","volume":"32","author":"Tang W. 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