{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:44:46Z","timestamp":1772981086845,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":325,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pediatrics"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study is aimed at describing the clinical and laboratory characteristics and determining the prevalence of microbial pathogens causing neonatal meningitis detected by cerebrospinal fluid (CSF) real\u2010time polymerase chain reaction (PCR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional descriptive study was conducted on 55 neonates diagnosed with meningitis. Pathogens were identified by using CSF real\u2010time PCR, CSF culture, or blood culture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Late\u2010onset meningitis accounted for 85.5% (47\/55) of cases. The most common clinical signs were respiratory distress (56.4%), fever (47.3%), and lethargy (34.5%). The median white blood cell count was 13,560\/mm\n                      <jats:sup>3<\/jats:sup>\n                      (8645\u201320,709\/mm\n                      <jats:sup>3<\/jats:sup>\n                      ), and the median absolute neutrophil count was 6063\/mm\n                      <jats:sup>3<\/jats:sup>\n                      (2895\u201312,508\/mm\n                      <jats:sup>3<\/jats:sup>\n                      ). C\u2010reactive protein levels were higher in full\u2010term neonates (8.55\u2009mg\/L) compared to preterm neonates (6.4\u2009mg\/L). The median CSF protein level was 1.4\u2009g\/L (1.1\u20131.73\u2009g\/L), with preterm neonates having significantly higher levels (1.59 vs. 1.22\u2009g\/L;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.013). Blood cultures identified seven cases. Real\u2010time PCR detected pathogens in only three cases (5.5%). No demographic or clinical factors were found to significantly differ between the groups with and without identified microbial pathogens (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Neonatal meningitis commonly manifests with respiratory distress, fever, and lethargy. While real\u2010time PCR enables the detection of viral and rare pathogens, its limited overall detection rate underscores the importance of early diagnosis based on clinical presentation and CSF analysis rather than exclusive reliance on microbiological evidence, which may delay essential treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijpe\/1852521","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T14:18:38Z","timestamp":1763821118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical, Laboratory Characteristics, and Microorganism Infection Status in Neonates With Meningitis in Vietnam: A Cross\u2010Sectional Descriptive Study"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0917-1805","authenticated-orcid":false,"given":"Tho Kieu 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