{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T05:34:10Z","timestamp":1793079250924,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":286,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pediatrics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mechanical ventilation (MV) is a frequent lifesaving therapy in very low birthweight (VLBW) infants, although it poses risks and may present complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the association between the use and duration of MV and survival without major morbidity (SWMM) in VLBW infants according to gestational age (GA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicenter retrospective study of prospectively collected data of premature infants weighing 500\u20131500\u2009g and 24\u201330 weeks of GA, born between 2010 and 2019 at NEOCOSUR Neonatal Network centers. Baseline characteristics and neonatal outcomes were compared between ventilated and nonventilated VLBW infants. Stratification for each week of GA was performed. Adjusted odds ratios and 95% confidence intervals (CIs) were calculated for main outcomes by logistic regression, adjusted for birthweight, GA, sex, mode of delivery, respiratory distress syndrome (RDS), antenatal corticosteroids, small for gestational age (SGA), and Apgar scores. Infants with congenital anomalies and those who died before discharge were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 7040 infants were included in the analysis. Among these, 4993 (70.9%) were ventilated and 2047 (29.1%) were not. Nonventilated infants were larger, healthier at birth, and presented fewer major adverse outcomes (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). SWMM in ventilated patients was 35.9%, compared with 73.4% in nonventilated infants (OR = 0.35; 95% CI: [0.31\u20130.40]). SWMM of ventilated infants remained lower at all GA intervals after risk adjustment. MV duration was also associated with a decrease in SWMM; each additional day of MV was associated with 7.9% lower odds of SWMM (OR = 0.921; 95% CI: [0.913\u20130.930]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use and duration of MV were associated with a significant decrease in SWMM in this population of VLBW infants, despite risk adjustment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijpe\/4067076","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:49:19Z","timestamp":1792043359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanical Ventilation and Survival Without Major Morbidity in Very\u2010Low\u2010Birth\u2010Weight Infants: A Multicenter Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3809-2567","authenticated-orcid":false,"given":"Alberto","family":"Toso","sequence":"first","affiliation":[{"name":"Department of Neonatology School of Medicine Pontificia Universidad Catolica de Chile  Santiago Chile  uc.cl"},{"name":"Red de Salud UC CHRISTUS  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4561-6210","authenticated-orcid":false,"given":"Daniela","family":"Kuzmanic","sequence":"additional","affiliation":[{"name":"Department of Neonatology School of Medicine Pontificia Universidad Catolica de Chile  Santiago Chile  uc.cl"},{"name":"Red de Salud UC CHRISTUS  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7477-7574","authenticated-orcid":false,"given":"Angelica","family":"Dominguez","sequence":"additional","affiliation":[{"name":"School of Public Health Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile  uc.cl"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0442-9109","authenticated-orcid":false,"given":"Alvaro","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Neonatology School of Medicine Pontificia Universidad Catolica de Chile  Santiago Chile  uc.cl"},{"name":"Red de Salud UC CHRISTUS  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8390-3675","authenticated-orcid":false,"given":"Cecilia","family":"Herbozo","sequence":"additional","affiliation":[{"name":"Universidad Peruana Cayetano Heredia Hospital Cayetano Heredia  Lima Peru  upch.edu.pe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0393-9753","authenticated-orcid":false,"given":"Pablo H.","family":"Brener Dik","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Neonatology Hospital Italiano de Buenos Aires  Buenos Aires Argentina  hospitalitaliano.org.ar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6612-5290","authenticated-orcid":false,"given":"Luis A.","family":"Ahumada","sequence":"additional","affiliation":[{"name":"Maternidad Provincial Brigadier Gral. Juan Bautista Bustos  Cordoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4864-6014","authenticated-orcid":false,"given":"Alvaro","family":"Mendez","sequence":"additional","affiliation":[{"name":"Hospital regional de Talca Dr. Cesar Garavagno Burotto  Talca Chile"},{"name":"Universidad Catolica del Maule  Talca Chile  ucm.cl"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Aburto","sequence":"additional","affiliation":[{"name":"Hospital Dr. Guillermo Grant Benavente  Concepcion Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6748-798X","authenticated-orcid":false,"given":"Jose L.","family":"Tapia","sequence":"additional","affiliation":[{"name":"Department of Neonatology School of Medicine Pontificia Universidad Catolica de Chile  Santiago Chile  uc.cl"},{"name":"Red de Salud UC CHRISTUS  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"NEOCOSUR Neonatal Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196702162760701"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0127-7"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.2401"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.5546\/aap.2017.eng.476"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.10.042"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2011.04.006"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.01.047"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.2.285"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001958"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.09.014"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-300143"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.3351"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3338"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.9.1124"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.05.039"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-315993"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000867"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-02129-2"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1880"},{"key":"e_1_2_11_21_2","first-page":"CD003063","volume-title":"Cochrane Database of Systematic Reviews","author":"Stevens T. 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