{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:03:02Z","timestamp":1792789382961,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":308,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pediatrics"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    A prospective observational study was conducted in 90 edematous children with steroid\u2010sensitive nephrotic syndrome (SSNS) to determine the prevalence of hypovolemia and also to study the role of surrogate markers like severe edema, high hematocrit, inferior vena cava collapsibility index (IVCCI) \u2265 50\n                    <jats:italic>%<\/jats:italic>\n                    , blood urea\/creatinine \u2265 100 : 1, and serum\u2009albumin &lt; 1.5 gm\/dL in identifying hypovolemia. The diagnostic test for hypovolemia was a combination of FeNa &lt; 0.5 and urinary potassium (UK) index \u2265 0.6. One\u2010third of children with SSNS had hypovolemia, of which 50% were symptomatic. High hematocrit was the most sensitive surrogate marker of hypovolemia (80%), followed by serum\u2009albumin &lt; 1.5\u2009g\/dL (56.6%), IVCCI \u2265 50\n                    <jats:italic>%<\/jats:italic>\n                    (43%), severe edema (36.7%), and blood urea\/creatinine \u2265 100 : 1 (33.3%). The specificity for detecting hypovolemia was maximum for IVCCI \u2265 50\n                    <jats:italic>%<\/jats:italic>\n                    (91.6%), followed by blood urea\/creatinine \u2265 100 : 1 (90%), serum\u2009albumin &lt; 1.5\u2009g\/dL (85%), severe edema (81.7%), and hemoconcentration (21.6%).\n                  <\/jats:p>","DOI":"10.1155\/ijpe\/5040795","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:22:48Z","timestamp":1762330968000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Utility of Clinical, Laboratory, and Radiological Parameters for Detecting Hypovolemia in Edematous Children With Steroid\u2010Sensitive Nephrotic Syndrome\u2014A Prospective Observational Study"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9752-9291","authenticated-orcid":false,"given":"N. 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