{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:56:43Z","timestamp":1781326603082,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":162,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pediatrics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this study was to compare the perioperative course and long\u2010term functional outcomes of children with early and late diagnosis of Hirschsprung\u2032s disease (HD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included patients affected by HD who underwent pull\u2010through between 1984 and 2015. Patients were classified into two groups: early diagnosis of HD (EDHD) before 1 year of age and late diagnosis of HD (LDHD) after 1 year. Functional outcomes at 3, 6, and 9 years after surgery were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and five patients, 83.8% with EDHD and 16.2% with LDHD. Abdominal distension and vomiting were the main presenting symptoms of EDHD, whereas chronic constipation was the primary symptom of LDHD. Preoperative intestinal obstruction occurred in 59.1% of EDHD versus 5.9% of LDHD (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001). Diverting colostomy was performed in 31.8% of EDHD versus 5.9% in LDHD (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03). Anal strictures needing anal dilatation occurred in 30.7% of EDHD versus 5.9% in LDHD (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03). At 3 years of follow\u2010up, there was a statistical difference in terms of constipation (10% in EDHD vs. 23.5% in LDHD;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.04), but not in terms of soiling (30.7% vs. 29.4%;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.65); 9 years after surgery, comparable results were shown in terms of both constipation and soiling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long\u2010term functional outcome is generally comparable between patients with EDHD and LDHD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijpe\/5593406","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:18:12Z","timestamp":1781324292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative and Long\u2010Term Functional Outcomes of Children With Early Diagnosis Versus Late Diagnosis of Hirschsprung\u2032s Disease: A 30\u2010Year Monocentric Retrospective Study"],"prefix":"10.1155","volume":"2026","author":[{"given":"Kamal","family":"El Haissoufi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9250-6487","authenticated-orcid":false,"given":"Francesca","family":"Nascimben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Lehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Chevalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Moog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Angotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Molinaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Becmeur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4496-6379","authenticated-orcid":false,"given":"Isabelle","family":"Talon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"e_1_2_15_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-022-05323-8"},{"key":"e_1_2_15_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2017.08.006"},{"key":"e_1_2_15_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2024.03.034"},{"key":"e_1_2_15_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2021.07.007"},{"key":"e_1_2_15_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002564"},{"key":"e_1_2_15_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.08.002"},{"key":"e_1_2_15_7_2","volume-title":"Hirschsprung\u2032s Disease and Allied Disorders","author":"Puri P.","year":"2008"},{"key":"e_1_2_15_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2008.07.005"},{"key":"e_1_2_15_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/pir.16.1.5"},{"key":"e_1_2_15_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1721081"},{"key":"e_1_2_15_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-012-3170-y"},{"key":"e_1_2_15_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-01668-x"},{"key":"e_1_2_15_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-018-0783-1"},{"key":"e_1_2_15_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-017-4187-z"},{"key":"e_1_2_15_15_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1744147"},{"key":"e_1_2_15_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-024-05657-5"},{"key":"e_1_2_15_17_2","doi-asserted-by":"publisher","DOI":"10.4103\/0189-6725.182562"},{"key":"e_1_2_15_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.04.022"},{"key":"e_1_2_15_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2023.10.018"},{"key":"e_1_2_15_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003550"},{"key":"e_1_2_15_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2021.04.024"},{"key":"e_1_2_15_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-018-3179-3"}],"container-title":["International Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ijpe\/5593406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/ijpe\/5593406","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ijpe\/5593406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:18:14Z","timestamp":1781324294000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/ijpe\/5593406"}},"subtitle":[],"editor":[{"given":"Marco","family":"Denina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/ijpe\/5593406"],"URL":"https:\/\/doi.org\/10.1155\/ijpe\/5593406","archive":["Portico"],"relation":{},"ISSN":["1687-9740","1687-9759"],"issn-type":[{"value":"1687-9740","type":"print"},{"value":"1687-9759","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5593406"}}