{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:47:03Z","timestamp":1769046423739,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pediatrics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In approximately 15% of cases undergoing surgery for acute appendicitis (AA), normal findings are observed in the histological examination of the appendix. Neurogenic appendicopathy (NA) is clinically indistinguishable from AA and is relatively less known. This retrospective study is designed to investigate the frequency of NA in patients operated on during the COVID\u201019 pandemic who were PCR\u2010negative for COVID\u201019 and showed no histological evidence of appendicitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Pediatric patients presenting with classic symptoms of AA (right lower quadrant pain, tenderness, and nausea\/vomiting) and supporting laboratory\/ultrasonographic findings underwent appendectomy based on standard clinical criteria.<\/jats:p>\n                    <jats:p>COVID\u201019 seronegative patients, who were operated on with a preliminary diagnosis of AA before and during the pandemic, were divided into two groups, each consisting of 20 randomly selected patients with similar age and equal gender distribution. The groups were defined as follows: Group 1: Patients who underwent surgery for AA before the pandemic and showed no histological evidence of appendicitis. Group 2: Patients who underwent surgery for AA during the pandemic, had no history of COVID\u201019, were PCR\u2010negative, and showed no histological evidence of appendicitis.<\/jats:p>\n                    <jats:p>The examination and laboratory findings of both groups were recorded. All appendix sections were stained with hematoxylin\u2013eosin and S\u2010100. The slides were independently analyzed and scored by two different pathologists (Observers 1 and 2) who were blinded to the patients\u2032 clinical histories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The ages, genders, fevers, vomiting, diarrhea, dysuria findings, white blood cell counts, C\u2010reactive protein levels, appendiceal diameters, and lengths of hospital stay of the 40 cases included in the study were recorded and compared. Statistically significant differences were found between the two groups in terms of fever, diarrhea, dysuria, and elevated white blood cell counts. In histological examination, both Observers 1 and 2\u2032s scores for Group 2 showed statistically significant differences in terms of NA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NA is characterized by a concentration of nerve cells in the appendix. It is clinically indistinguishable from AA but can be identified through histopathological examination. During the pandemic, in cases with symptoms of AA but no histological evidence, S\u2010100 staining of the samples revealed a concentration of nerve fibers in the region. These findings suggest that even PCR\u2010negative cases may still be affected by the virus during the pandemic or that the virus may have a localized interaction with the gastrointestinal system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijpe\/7391055","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T10:55:51Z","timestamp":1768992951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurogenic Appendicopathy in Pediatric Appendectomies During the COVID\u201019 Era: A Retrospective Analysis of Histologically Negative Cases"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2591-0655","authenticated-orcid":false,"given":"Yavuz","family":"Yilmaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3666-295X","authenticated-orcid":false,"given":"Elif Emel","family":"Erten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2498-0472","authenticated-orcid":false,"given":"Merve Meryem","family":"Kiran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4835-3639","authenticated-orcid":false,"given":"Duriye Ozer","family":"Turkay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115734"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-020-00306-3"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.0479"},{"key":"e_1_2_9_4_2","first-page":"262","article-title":"Les L\u00e9sions Nerveuses De L\u00e1ppendicite Chronique","author":"Masson M. 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