{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T16:05:20Z","timestamp":1779725120793,"version":"3.53.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":144,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012521","name":"Universitas Gadjah Mada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012521","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Vascular Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Serum activin A level is a promising prognostic biomarker for pulmonary artery hypertension (PAH). In this study, we aim to investigate serum activin A levels and their associations with 1\u2010year mortality in atrial septal defect (ASD)\u2013associated PAH patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a case\u2010control study of adult Indonesian patients diagnosed with ASD\u2010PAH from the COHARD\u2010PH registry. Cases were subjects deceased in a 1\u2010year follow\u2010up, whereas controls were those survived. Serum activin A was measured at the index of diagnosis. The demographics, clinical parameters, hemodynamic, and mortality data were retrieved from the registry database up to a 1\u2010year follow\u2010up period. These data were compared and analyzed between the case and control groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From the 1\u2010year follow\u2010up data, 44 cases (deceased group) and 102 controls (survived group) were identified. The deceased group had significant lower bodyweight (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), body mass index (BMI) (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01), with higher NT\u2010proBNP level (&lt;\u20090.0001), higher proportion of Eisenmenger syndrome (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05), higher right atrial (RA) area (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001), lower tricuspid annular plane systolic excursion (TAPSE) (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01), and a significant increase in mean right atrial pressure (mRAP) (&lt;\u20090.0001). There was no difference in the activin A level between deceased and survivors (506.3 \u00b1 259.1\u2009pg\/mL vs. 536.1 \u00b1 293.9\u2009pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05, respectively). Moreover, activin A level did not associate with the mortality risk among subjects (OR = 0.9996; 95% CI: 0.9982\u20131.00087;\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum activin A level did not associate with 1\u2010year mortality in adult patients with ASD\u2010associated PAH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijvm\/7787559","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T15:35:41Z","timestamp":1779723341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Activin A Level and 1\u2010Year Mortality in Atrial Septal Defect\u2010Associated Pulmonary Artery Hypertension: A Case\u2010Control Study From the COHARD\u2010PH Registry"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9316-4234","authenticated-orcid":false,"given":"Pranindya","family":"Rinastiti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6373-1033","authenticated-orcid":false,"given":"Anggoro Budi","family":"Hartopo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6338-1943","authenticated-orcid":false,"given":"Cindy Elica","family":"Cipta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syallom Gita","family":"Maharani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6454-518X","authenticated-orcid":false,"given":"Dyah Wulan","family":"Anggrahini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6673-2616","authenticated-orcid":false,"given":"Noriaki","family":"Emoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4011-2184","authenticated-orcid":false,"given":"Lucia Kris","family":"Dinarti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02341-2020"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACBTS.2024.04.005"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21961-3"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaz5660"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90719.2008"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.061501"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.5334\/GH.944"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/PUL2.12280"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/S12872-020-01434-Z"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS24043332"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAUT.2019.102314"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2213558"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00106"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJCCHD.2024.100525"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/HHF.0000000000000080"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-024-01872-8"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/AJH\/HPX185"}],"container-title":["International 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