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Patients were divided into 4 groups according to the clinical condition of the disease, the group of patients hospitalized in the intensive care unit, hospitalized patients who did not require intensive care unit, COVID\u201019 patients who did not require hospitalization, and a control group. It was determined that 64.8% of the patients evaluated were men. Patients hospitalized in the ICU were 11.25 times more likely to have a cough and 36.7 times more likely to have a fever compared to the control group. In the group of hospitalized patients who did not require ICU, the presence of cough was 9.44 times higher than in the control group. The lowest IL\u20106 values were obtained in the group of COVID\u201019 patients who did not require hospitalization (2\u2009pg\/mL) and the highest in the ICU group (168.5\u2009pg\/mL). On the other hand, the highest values of the micronutrient zinc were also obtained in the ICU group (3402.5\u2009\u03bcg\/dL). In this group, the highest values of lymphocytes, C\u2010reactive protein, and lactate dehydrogenase were also found with statistical significance compared to the group of hospitalized patients who did not require ICU. In conclusion, patients with COVID\u201019 in the ICU had higher levels of IL\u20106 and zinc compared to the other groups. This group also had the highest levels of lymphocytes, C\u2010reactive protein, and lactate dehydrogenase compared to the group of hospitalized patients who did not require ICU care.<\/jats:p>","DOI":"10.1155\/ipid\/6486467","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:29:36Z","timestamp":1749727776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determination of Serum Levels of Interleukin\u20106 and the Trace Element Zinc According to the Clinical Status of Patients With COVID\u201019"],"prefix":"10.1155","volume":"2025","author":[{"given":"Andrea","family":"Roman-Pimentel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Medina-C\u00e1ceres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6011-5040","authenticated-orcid":false,"given":"Juana del","family":"Valle-Mendoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7023-3190","authenticated-orcid":false,"given":"Miguel Angel","family":"Aguilar-Luis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungmin","family":"Kym","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9100-8547","authenticated-orcid":false,"given":"Ronald","family":"Aquino-Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0740-4502","authenticated-orcid":false,"given":"Yordi","family":"Tarazona-Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7886-8895","authenticated-orcid":false,"given":"Hugo","family":"Carrillo-Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliezer Bonifacio-Velez de","family":"Villa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-8084","authenticated-orcid":false,"given":"Wilmer","family":"Silva-Caso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/21501319231206911"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12071609"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12839"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2020.07.001"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0311-8"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00733-x"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.05.008"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01057"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1759720x10378372"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0419-z"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2032911"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400761"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-020-02437-9"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3mt00353a"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu9121286"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.606398"},{"key":"e_1_2_14_17_2","volume-title":"Direcci\u00f3n General de Intervenciones Estrat\u00e9gicas en Salud P\u00fablica. 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