{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:02:21Z","timestamp":1772989341731,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":59,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Analytical Methods in Chemistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:italic>Albiziae Flos<\/jats:italic>\n                    (AF) is a traditional Chinese medicine with an extensive historical background. This study presented an integrated approach combining headspace\u2013gas chromatography\u2013mass spectrometry (HS\u2013GC\u2013MS), chemometrics, and network pharmacology to comprehensively evaluate the volatile components of AF and explore their potential antidepressant mechanisms. A total of 34 volatile compounds were identified through HS\u2013GC\u2013MS analysis. Fingerprint assessment revealed high consistency among 16 batches (similarity: 0.790\u20130.998), while chemometric analysis successfully discriminated samples from different geographical origins. Network pharmacology screening identified 15 active components and 131 potential targets, revealing multicomponent, multitarget characteristics of AF\u2019s antidepressant effects. Molecular docking simulations demonstrated strong binding affinity between linalool oxide configurations and 12 core targets, primarily through hydrogen bonding and hydrophobic interactions. This work lies in its comprehensive investigation of AF\u2019s volatile components using an integrated analytical\u2013pharmacological approach, providing both a methodological framework for quality assessment and mechanistic insights for antidepressant drug development. Our findings established scientific foundations for quality control of AF and revealed its potential antidepressant mechanisms through multiple pathways.\n                  <\/jats:p>","DOI":"10.1155\/jamc\/2885034","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:52:34Z","timestamp":1772970754000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploration of Potential Antidepressant Active Ingredients of\n                    <i>Albiziae Flos<\/i>\n                    via HS\u2013GC\u2013MS, Chemometrics, and Network Pharmacology"],"prefix":"10.1155","volume":"2026","author":[{"given":"Dan","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1600-130X","authenticated-orcid":false,"given":"Dan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4547-2445","authenticated-orcid":false,"given":"Yiwu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1583-2021","authenticated-orcid":false,"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,1]]},"reference":[{"key":"e_1_2_11_1_2","volume-title":"Pharmacopoeia of the people\u2032s Republic of China","author":"Chinese Pharmacopoeia Commission","year":"2020"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1001-1528.2022.08.034"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1002-2619.2007.07.052"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201700252"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.13193\/j.issn.1673-7717.2023.06.017"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1005-8257.2025.15.007"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.13517\/j.cnki.ccm.2013.03.056"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.05.018"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.19738\/j.cnki.psy.2023.06.069"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1671-038X.2022.06.04"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/0115748855338072241122141859"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26167778"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1006-5687.2022.02.015"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.16333\/j.1001-6880.2024.1.015"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.14009\/j.issn.1672-2124.2021.01.014"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1007-8517.2020.18.zgmzmjyyzz202018013"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.19656\/j.cnki.1002-2406.2015.02.018"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.5246\/jcps.2017.11.090"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.14088\/j.cnki.issn0439-8114.2012.06.020"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.136270"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom9080362"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.19378\/j.issn.1003-9783.2019.02.004"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-020-2155-7"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.07.046"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-025-04841-x"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.20231013.703"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.2174\/1573409919666230619105254"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S270757"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2016.1228682"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1002-2619.2007.07.052"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1008-0805.2000.07.005"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/separations10110553"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1039\/d1fo02120f"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8858093"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/plants13162206"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2022.112386"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.16155\/j.0254-1793.2021.10.03"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.16155\/j.0254-1793.2021.10.03"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2013.12.001"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.132461"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/agriculture14040573"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.3390\/foods12061162"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.7501\/j.issn.0253-2670.2016.09.001"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.2174\/0115701808269296231019055844"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113549"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.70041"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X18666201015155816"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112150-20210111-00026"},{"key":"e_1_2_11_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11094-023-02942-w"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118098"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27185883"},{"key":"e_1_2_11_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-022-00930-9"},{"key":"e_1_2_11_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-025-04419-6"},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c08350"}],"container-title":["Journal of Analytical Methods in Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jamc\/2885034","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/jamc\/2885034","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jamc\/2885034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:52:54Z","timestamp":1772970774000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/jamc\/2885034"}},"subtitle":[],"editor":[{"given":"Luca","family":"Tortora","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/jamc\/2885034"],"URL":"https:\/\/doi.org\/10.1155\/jamc\/2885034","archive":["Portico"],"relation":{},"ISSN":["2090-8865","2090-8873"],"issn-type":[{"value":"2090-8865","type":"print"},{"value":"2090-8873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2885034"}}