{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:07:39Z","timestamp":1789495659517,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":236,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Analytical Methods in Chemistry"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Mango peel is one of the main byproducts in mango processing. In order to improve the utilization and added\u2010value of mango peel, effects of the ultrasound\u2010assisted enzymatic method on the extraction rate of mangiferin from mango peel were investigated by single\u2010factor tests (enzyme addition amount, enzymolysis time, ethanol concentration, ultrasonic temperature, ultrasonic power, and ultrasonic time), and the extraction process was optimized by Box\u2013Behnken response surface. The antioxidant activity and antidiabetic assay of mangiferin in vitro were studied. The results showed that enzymolysis time 44\u2009min, enzyme addition amount 0.1%, ethanol concentration 70%, ultrasonic power 300\u2009W, ultrasonic temperature 66\u00b0C, and ultrasonic time 45\u2009min were the optimal extraction process parameters. Under these conditions, the extraction rate of mangiferin was 3.63%\u2009\u00b1\u20090.04%, which was not significantly different from the model prediction value (3.71%), and it was 3.90 times and 1.78 times that of single cellulase and ultrasonic extraction, respectively. Within the test concentration range, the scavenging rate of mangiferin for DPPH\u00b7, ABTS\n                    <jats:sup>+<\/jats:sup>\n                    \u00b7, and O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u00b7 increased with the increase of its mass concentration, and the EC\n                    <jats:sub>50<\/jats:sub>\n                    values were 0.03829\u2009mg\/mL, 0.06032\u2009mg\/mL, and 0.04949\u2009mg\/mL, respectively, which were slightly higher than those of Vc. Meanwhile, mangiferin exhibited inhibitory activity effects on \u03b1\u2010amylase and \u03b1\u2010glucosidase, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 0.1952 and 0.08696\u2009mg\/mL, respectively. Results indicate that the mangiferin in mango peel had strong bioactivity. The study provides a theoretical reference for the efficient extraction of mangiferin from mango peel and provides a scientific basis for further realizing the high\u2010value utilization of mango processing waste.\n                  <\/jats:p>","DOI":"10.1155\/jamc\/3469361","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T11:49:13Z","timestamp":1756122553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ultrasound\u2010Assisted Enzymatic Extraction of Mangiferin From Mango (\n                    <i>Mangifera indica<\/i>\n                    L.) Peels: Process Optimization and Antioxidant Activity Evaluation"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3134-8308","authenticated-orcid":false,"given":"Kaiping","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinjiabao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6335-1379","authenticated-orcid":false,"given":"Jiaoli","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-021-05304-0"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.13982\/j.mfst.1673-9078.2022.7.0405"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-020-04731-9"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11694-024-02446-5"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11947-019-02317-8"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.13840\/j.cnki.cn21-1457\/tq.2023.09.033"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13399-024-05606-1"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11694-024-02441-w"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-023-04225-w"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.17113\/ftb.62.02.24.8258"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-022-02373-6"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95663-7"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43094-023-00472-6"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s43450-022-00297-z"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-023-02682-4"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-019-03909-0"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.5246\/jcps.2021.10.071"},{"key":"e_1_2_10_18_2","first-page":"161","article-title":"Optimization of Ultrasound Assisted Extraction of Mangiferin in Mango (Mangifera indica L.) 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