{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T08:22:36Z","timestamp":1787559756222,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":235,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Analytical Methods in Chemistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    High\u2010resolution MS techniques such as time\u2010of\u2010flight (TOF)\u2010MS are preferred for putative metabolite identification due to their unprecedented high resolution and accuracy in metabolomics studies. However, exploring cost\u2010effective alternative instruments for routine analyses would be advantageous, particularly in laboratories where access to high\u2010resolution mass spectrometry (MS) is limited. This study investigated the ability of the LC\u2010QQQ\u2010MS instrument operating in Q3 scan mode in replicating results obtained from the qTOF\u2010MS. Methanolic extracts of non\u2010treated and UV\u2010treated samples of\n                    <jats:italic>Viscum combreticola<\/jats:italic>\n                    were used as model samples for the analysis. Multivariate statistical models including principal component analysis (PCA), hierarchical clustering analysis and volcano plots were employed to highlight metabolite differences between UV\u2010treated and non\u2010treated plant extracts. The findings of this study demonstrated that the LC\u2010QQQ\u2010MS is effective in distinguishing between the two contrasting extracts of\n                    <jats:italic>V. combreticola<\/jats:italic>\n                    . Several\n                    <jats:italic>cis<\/jats:italic>\n                    isomers of hydroxycinnamic acid containing molecules such as 3\u2010feruloylquinic acid, 4,5\u2010dicaffeoylquinic acid and 4\u2010\n                    <jats:italic>p<\/jats:italic>\n                    \u2010coumaroyl\u20105\u2010caffeoylquinic acids that underwent geometrical isomerization following UV exposure were identified as differentiating molecules (biomarkers), consistent with previous findings using high\u2010resolution qTOF\u2010MS instruments. This study positions QQQ\u2010MS as a valuable tool for authenticating samples containing known metabolites, particularly when the identification of unknowns is not the primary objective and high\u2010resolution MS instruments are not accessible.\n                  <\/jats:p>","DOI":"10.1155\/jamc\/7032335","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T08:10:33Z","timestamp":1787559033000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LC\u2010Triple Quadrupole MS Enables Sample Classification in\n                    <i>Viscum combreticola<\/i>\n                    : Detecting Subtle Photochemical Isomerization in Hydroxycinnamic Acid Derivatives"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3143-797X","authenticated-orcid":false,"given":"Mailane 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