{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:18:08Z","timestamp":1781720288410,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":329,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007941","name":"Addis Ababa University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parasitology Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Background<\/jats:bold>: Schistosomiasis continues to be a major public health concern in Ethiopia. Eliminating the intermediate host snails is an effective and cost\u2010efficient strategy for preventing and controlling schistosomiasis transmission. However, chemical molluscicides have limitations due to their toxicity to nontarget aquatic organisms, environmental concerns, and the development of resistance. Plant\u2010based molluscicides are biodegradable, less toxic, safe, and cost\u2010effective.<\/jats:p><jats:p><jats:bold>Objective<\/jats:bold>: This study is aimed at evaluating the molluscicidal activity of <jats:italic>Hagenia abyssinica<\/jats:italic> flowers, <jats:italic>Rosa abyssinica<\/jats:italic> fruits, and <jats:italic>Cucumis ficifolius<\/jats:italic> roots against <jats:italic>Biomphalaria<\/jats:italic> and <jats:italic>Bulinus<\/jats:italic> species.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold>: Adult <jats:italic>Biomphalaria<\/jats:italic> and <jats:italic>Bulinus<\/jats:italic> species were subjected to varying concentrations of aqueous and 70% ethanol extracts and solvent partitions from <jats:italic>H. abyssinica<\/jats:italic>, <jats:italic>R. abyssinica<\/jats:italic>, and <jats:italic>C. ficifolius<\/jats:italic> for 24, 48, and 72\u2009h. The investigation involved conducting a phytochemical analysis using standard screening methods. Female mice were subjected to an acute oral toxicity test using a 70% ethanol extract of <jats:italic>H. abyssinica<\/jats:italic>, <jats:italic>R. abyssinica<\/jats:italic>, and <jats:italic>C. ficifolius<\/jats:italic>. The mortality data were then determined using GraphPad Prism 9 software.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>: Aqueous and 70% ethanol extracts of <jats:italic>R. abyssinica<\/jats:italic> and <jats:italic>C. ficifolius<\/jats:italic> did not exhibit molluscicidal activities against <jats:italic>Biomphalaria<\/jats:italic> and <jats:italic>Bulinus<\/jats:italic> species. However, aqueous, 70% ethanol, and chloroform extracts of <jats:italic>H. abyssinica<\/jats:italic> showed significant molluscicidal activities against <jats:italic>Biomphalaria<\/jats:italic> species with 24\u2010h LC<jats:sub>50<\/jats:sub> values of 39.05, 11.93, and 5.52\u2009mg\/L, respectively. Similarly, the LC<jats:sub>50<\/jats:sub> values of the same extracts against <jats:italic>Bulinus<\/jats:italic> species after 24\u2009h of exposure were 40.08, 12.23, and 6.13\u2009mg\/L, respectively. The plant extract\u2019s LD<jats:sub>50<\/jats:sub> for acute toxicity against mice was found to be over 2000\u2009mg\/kg of body weight.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold>: <jats:italic>H. abyssinica<\/jats:italic> demonstrated potent molluscicidal activity, making it a potential candidate for application. Further isolation of active ingredients and field trials are necessary to determine the optimal conditions for its use in snail control.<\/jats:p>","DOI":"10.1155\/japr\/7968654","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T12:34:09Z","timestamp":1732538049000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Molluscicidal Activity of Extracts and Fractions From <i>Hagenia abyssinica<\/i>, <i>Rosa abyssinica<\/i>, and <i>Cucumis ficifolius<\/i> Against <i>Biomphalaria<\/i> and <i>Bulinus<\/i> Snails"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5117-9819","authenticated-orcid":false,"given":"Hirut","family":"Basha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asfaw","family":"Debella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5301-9923","authenticated-orcid":false,"given":"Milkyas","family":"Endale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7239-3788","authenticated-orcid":false,"given":"Eyob","family":"Debebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meharu","family":"Mathewos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tesfaye","family":"Biftu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9541-8976","authenticated-orcid":false,"given":"Hassen","family":"Mamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"e_1_2_14_1_2","volume-title":"A Global Brief on Vector-Borne Diseases","author":"World Health Organization","year":"2014"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.4314\/ejhs.v21i2.69051"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2008.00575.x"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70521-7"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40794-020-00127-x"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133142"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-1804-4"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-08957-2"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed8030154"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.3923\/aje.2010.123.140"},{"key":"e_1_2_14_11_2","first-page":"65","article-title":"Prevention and control of schistosomiasis: a current perspective","volume":"5","author":"Inobaya M. 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