{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:07:07Z","timestamp":1791295627803,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":359,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018726","name":"Torbat Heydariyeh University of Medical Sciences","doi-asserted-by":"publisher","award":["SRC-98-137"],"award-info":[{"award-number":["SRC-98-137"]}],"id":[{"id":"10.13039\/100018726","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parasitology Research"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cystic echinococcosis (CE) remains an important public health challenge in endemic regions of Iran, especially in areas with intensive livestock farming and close human\u2013animal contact. Long\u2010term epidemiological analyses are essential for identifying patterns, informing control strategies, and evaluating intervention outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A 17\u2010year cross\u2010sectional study design based on retrospective data (2006\u20132022) was conducted on surgically confirmed human CE cases from two referral hospitals in Razavi Khorasan Province, northeastern Iran. Demographic, clinical, and spatial data from patients residing in Torbat\u2010e Heydariyeh, Zaveh, Mahvelat, and Roshtkhar were reviewed. Descriptive and inferential statistical analyses were performed using SPSS v.25, including chi\u2010square, Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      , and one\u2010way ANOVA tests (\n                      <jats:italic>\u03b1<\/jats:italic>\n                      = 0.05). Temporal trends were assessed using Poisson regression, and case distribution was visualized via GIS\u2010based heatmapping (ArcGIS Pro 3.2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 232\u2009CE surgical cases were recorded during a 17\u2010year period, corresponding to an average annual incidence of 13.6 and a surgical incidence rate of 3\/100,000 population. The liver was the most affected organ (81.5%), and abdominal pain was the most frequent presenting symptom (73.7%). Two age peaks were observed at 21\u201340 and \u2265\u200961 years. Females (57.8%) and urban residents (64.7%) comprised the majority of patients. Regression analysis indicated a nonsignificant declining trend over time (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = \u22120.95, 95% CI: \u22122.71\u20130.81,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.26). A statistically significant association was found between residency and organ involvement in patients with CE (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 5.78, df = 1,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.016).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This 17\u2010year analysis reveals persistent CE burden in northeastern Iran despite a modest decline in recent years. Sustained One Health surveillance, public education, and strengthened veterinary\u2013human collaboration are required to mitigate disease transmission and improve control outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/japr\/8605086","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T12:16:53Z","timestamp":1766751413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010Term Epidemiological Insights Into Human Cystic Echinococcosis in Northeastern Iran: A 17\u2010Year Retrospective Analysis"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8450-8175","authenticated-orcid":false,"given":"Seyed-Sajjad","family":"Alavi-Kakhki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8725-7452","authenticated-orcid":false,"given":"Mohammad","family":"Ghorbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0946-8964","authenticated-orcid":false,"given":"Seyed-Reza","family":"Mirbadie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1860-326X","authenticated-orcid":false,"given":"Milad","family":"Badri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4444-8782","authenticated-orcid":false,"given":"Mohammad-Reza","family":"Rezaiemanesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0933-8134","authenticated-orcid":false,"given":"Nooshin","family":"Hashemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3351-7965","authenticated-orcid":false,"given":"Zahra","family":"Jabalameli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2310-0544","authenticated-orcid":false,"given":"Ali","family":"Gholizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8301-5256","authenticated-orcid":false,"given":"Mohammad-Ali","family":"Mohaghegh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"e_1_2_11_1_2","first-page":"91","article-title":"Analysis of the COX1 Gene in Echinococcus granulosus From Sheep in Northeast Iran Using PCR High-Resolution Melting (qPCR-HRM) Curve Analysis","volume":"35","author":"Mohaghegh M. 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