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An early involvement\nof RNA oxidation of vulnerable neuronal population in the\nneurodegenerative diseases has been demonstrated, which is\nstrongly supported by a recent observation of increased RNA\noxidation in brains of subjects with mild cognitive impairment.\nUntil recently, little is known about consequences and cellular\nhandling of the RNA damage. However, increasing body of evidence\nsuggests detrimental effects of the RNA damage in protein\nsynthesis and the existence of several coping mechanisms including\ndirect repair and avoiding the incorporation of the damaged\nribonucleotides into translational machinery. Further\ninvestigations toward understanding of the consequences and\ncellular handling mechanisms of the oxidative RNA damage may\nprovide significant insights into the pathogenesis and therapeutic\nstrategies of the neurodegenerative diseases.<\/jats:p>","DOI":"10.1155\/jbb\/2006\/82323","type":"journal-article","created":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T09:58:55Z","timestamp":1150711135000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Oxidative Damage to RNA in Neurodegenerative 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