{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:17:40Z","timestamp":1785367060614,"version":"3.55.0"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P50AG05128"],"award-info":[{"award-number":["P50AG05128"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG07198"],"award-info":[{"award-number":["R01AG07198"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>Autopsy information on cardiovascular damage was investigated for pathologically confirmed Alzheimer disease (AD) patients (<jats:italic>n<\/jats:italic> = 84) and non\u2010AD control patients (<jats:italic>n<\/jats:italic> = 60). The 51 relevant items were entered into a grade\u2010of\u2010membership model to describe vascular damage in AD. Five latent groups were identified \u201cI: early\u2010onset AD,\u201d \u201cII: controls, cancer,\u201d \u201cIII: controls, extensive atherosclerosis,\u201d \u201cIV: late\u2010onset AD, male,\u201d and \u201cV:\nlate\u2010onset AD, female.\u201d Expectedly, Groups IV and V had elevated <jats:italic>APOE<\/jats:italic><jats:italic>\u03b5<\/jats:italic>4 frequency. Unexpectedly, there was limited atherosclerosis and frequent myocardial valve and ventricular damage. The findings do not indicate a strong relationship between atherosclerosis and AD, although both are\nassociated with the <jats:italic>APOE<\/jats:italic><jats:italic>\u03b5<\/jats:italic>4. Instead, autopsy findings of extensive atherosclerosis were associated with possible, not probable or definite AD, and premature death. They are consistent with the hypothesis that brain hypoperfusion contributes to dementia, possibly to AD pathogenesis, and raise the possibility that the <jats:italic>APOE<\/jats:italic> allele  <jats:italic>\u03b5<\/jats:italic>4 contributes directly to heart valve and myocardial damage.<\/jats:p>","DOI":"10.1155\/jbb.2005.189","type":"journal-article","created":{"date-parts":[[2005,6,30]],"date-time":"2005-06-30T17:42:16Z","timestamp":1120153336000},"page":"189-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Cardiovascular Damage in Alzheimer Disease: Autopsy Findings From the Bryan ADRC"],"prefix":"10.1155","volume":"2005","author":[{"given":"Elizabeth H.","family":"Corder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Ervin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Lockhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari H.","family":"Szymanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald E.","family":"Schmechel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Hulette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,30]]},"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2005\/709642.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/JBB.2005.189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T16:17:22Z","timestamp":1722356242000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/JBB.2005.189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1155\/JBB.2005.189"],"URL":"https:\/\/doi.org\/10.1155\/jbb.2005.189","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"2004-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-12-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}