{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:56:49Z","timestamp":1790006209852,"version":"4.0.1"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>HLA alleles have been associated with psoriasis. Toxin\u2010producing\nstrains of <jats:italic>Staphylococcus aureus<\/jats:italic> behave as superantigens, and \nif present in patients, might play a role in the exacerbation\nof psoriatic lesions by activating certain V\u2010beta (V<jats:italic>\u03b2<\/jats:italic>) T\u2010lymphocyte subsets. Allele frequencies in 22 patients and 22\ncontrols (alleles determined by DNA\/SSP typing) were used to calculate a relative risk \nof 4.7 (<jats:italic>P<\/jats:italic> &lt; .05) for HLA\u2010Cw6. <jats:italic>S aureus<\/jats:italic> was isolated from the throat of 11 \npatients. Enterotoxins A and C were detected by agglutination in the culture filtrate of one \nisolate. The enterotoxin A and\/or C genes were detected by PCR in 9 isolates, and \ntranscripts were detected by RT\u2010PCR in 7 of them. None of the isolates from controls \nharbored enterotoxin genes. V<jats:italic>\u03b2<\/jats:italic> expansions were detected by RT\u2010PCR in all 22 patients. Low or \nno V<jats:italic>\u03b2<\/jats:italic> expansions were obtained in controls. The association of HLA\u2010Cw6 with \npsoriasis in Lebanese concurs with that reported for other ethnic groups. \nToxin\u2010producing isolates that colonize patients might play a role in the\nexacerbation of psoriatic lesions.<\/jats:p>","DOI":"10.1155\/jbb.2005.310","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T12:55:00Z","timestamp":1135169700000},"page":"310-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["HLA Allele Associations and V\u2010Beta T\u2010Lymphocyte Expansions inPatients With Psoriasis, Harboring Toxin\u2010Producing <i>Staphylococcus aureus<\/i>"],"prefix":"10.1155","volume":"2005","author":[{"given":"Rola","family":"Ajib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Janbazian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Rahal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghassan M.","family":"Matar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shukrallah","family":"Zaynoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul-Ghani","family":"Kibbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.","family":"Abdelnoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2005\/945072.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2005\/945072.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/JBB.2005.310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T11:51:37Z","timestamp":1722340297000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/JBB.2005.310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1155\/JBB.2005.310"],"URL":"https:\/\/doi.org\/10.1155\/jbb.2005.310","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"2005-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}