{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:27:09Z","timestamp":1760707629992},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>This report evaluates the significance of antibody\/bovine serum albumin \n(BSA) interactions as a risk factor for the diagnosis of acute hepatitis E. Serum samples \nfrom 40 patients with acute hepatitis E and from 40 age\/sex matched healthy adult subjects\nwere tested for IgA, IgG, and IgM by ELISA and by turbidimetric assay. BSA was used as a \ntarget to characterize changes in levels of interacting immunoglobulins. Initial results \nobtained before removal of antibodies that interacted with BSA suggested that HEV\npatients had increased levels of IgM in their sera. It was found\nthat normal individuals had mean IgA, IgG, and IgM levels of 2.55 mg\/mL, 9.80 mg\/mL, and 1.73 mg\/mL, respectively while HEV patients had mean levels of 2.66 mg\/mL, 10.04 mg\/mL, and 2.01 mg\/mL (<jats:italic>P<\/jats:italic> &lt; .26, <jats:italic>P<\/jats:italic> &lt; .32, and <jats:italic>P<\/jats:italic> &lt; .0004). However, the mean level of IgM in HEV\u2010infected sera after purification from \nantibodies that interacted with BSA was determined to be 1.72 mg\/mL indicating that there was no significant difference in IgM level\nin HEV patients compared to normal individuals (<jats:italic>P<\/jats:italic> &lt; .6). The presence of antibodies that interact with BSA might serve as a\ndiagnostic tool for detection of high\u2010risk patients.<\/jats:p>","DOI":"10.1155\/jbb.2005.316","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T12:55:00Z","timestamp":1135169700000},"page":"316-321","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bovine Serum Albumin Antibodies as a Disease Marker for Hepatitis EVirus Infection"],"prefix":"10.1155","volume":"2005","author":[{"given":"Medhat","family":"Haroun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2005\/374875.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/JBB.2005.316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T11:51:28Z","timestamp":1722340288000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/JBB.2005.316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1155\/JBB.2005.316"],"URL":"https:\/\/doi.org\/10.1155\/jbb.2005.316","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"2005-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}