{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:26:27Z","timestamp":1793726787987,"version":"4.6.1"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":280,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009501"],"award-info":[{"award-number":["2022YFC2009501"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>This systematic review and network meta\u2010analysis is aimed at comparing the efficacy and safety of various wound dressings in the treatment of diabetic foot ulcers, as differences in outcomes among these materials remain unclear. A comprehensive literature search was conducted across major Chinese and international databases up to October 2024, identifying 35 randomized controlled trials involving 2631 patients. Data were extracted and quality\u2010assessed using standardized methods, and a network meta\u2010analysis was performed using appropriate statistical software. The results showed that, compared with traditional dressings, novel biomaterials (e.g., growth factors, amniotic membrane, platelet\u2010rich plasma, and hydrogels) and antimicrobial dressings (e.g., silver ion dressings) combined with basic fibroblast growth factor or hydrogel significantly shortened wound healing time. In terms of healing efficiency, combinations involving epidermal growth factor, amniotic membrane, or platelet\u2010rich plasma with hydrogel were significantly more effective than traditional dressings. The surface under the cumulative ranking curve values indicated that the most effective interventions were antimicrobial dressings (silver ion) combined with basic fibroblast growth factor for wound healing time and epidermal growth factor\u2013based regimens for healing efficiency. Importantly, sensitivity analyses excluding studies at high risk of bias (allocation\/blinding) demonstrated that the ranking for ulcer healing time was unstable\u2014attenuated for platelet\u2010rich plasma but more favorable for honey dressings\u2014whereas estimates for healing efficiency remained robust. These findings suggest that conclusions regarding healing time are particularly sensitive to study quality and should be interpreted with caution. No serious adverse events were reported, and most interventions were well tolerated. These findings suggest that biomaterial and antimicrobial dressings, particularly when used in combination with traditional methods, offer clear advantages in the management of diabetic foot ulcers and should be prioritized in clinical practice.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    CRD42024578762\n                  <\/jats:p>","DOI":"10.1155\/jdr\/1548984","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:49:01Z","timestamp":1759992541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and Safety of Biomaterials and Antimicrobial Dressings in the Treatment of Diabetic Foot Ulcers: A Systematic Review and Network Meta\u2010Analysis"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0615-2817","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7298-6695","authenticated-orcid":false,"given":"Yanan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexinyao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2653-8496","authenticated-orcid":false,"given":"Liwei","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_2_13_1_2","first-page":"1287","article-title":"Chinese Guideline for the Diagnosis and Treatment of Diabetic Foot, [in Chinese]","volume":"52","author":"Gu Y. 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