{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:57:23Z","timestamp":1783407443169,"version":"3.54.6"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":99,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Metabolically\u2010dysfunction\u2010associated steatohepatitis (MASH) is the progressive form of metabolic dysfunction\u2010associated steatotic liver disease (MASLD) and is strongly linked to obesity and type 2 diabetes mellitus (T2D). Tirzepatide, a dual glucose\u2010dependent insulinotropic polypeptide (GIP)\/glucagon\u2010like peptide\u20101 (GLP\u20101) receptor agonist, has emerged as a promising therapeutic option due to its profound metabolic effects and potential hepatic benefits. This study integrates bibliometric mapping with current clinical evidence to evaluate tirzepatide\u2019s role in MASLD\/MASH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A bibliometric search was conducted in the Web of Science Core Collection (2018\u20132025) using predefined keywords related to tirzepatide and metabolic liver disease. Twenty\u2010five full\u2010text publications\u2014including randomized controlled trials, post hoc analyses, meta\u2010analyses, mechanistic reviews, and international guidelines\u2014were systematically reviewed. Co\u2010occurrence networks were generated using VOSviewer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Scientific output on tirzepatide and MASLD\/MASH has increased rapidly since 2020, with thematic clusters centered on metabolic regulation, hepatic inflammation, and fibrosis. Clinical evidence shows that tirzepatide induces substantial weight loss, improves glycaemic control, and reduces hepatic biomarkers such as ALT, AST, K 18, and Pro C3. The SYNERGY\u2010nonalcoholic steatohepatitis (NASH) trial demonstrated high rates of MASH resolution without fibrosis worsening and meaningful fibrosis regression at 52 weeks. Network meta\u2010analyses position tirzepatide among the most effective therapies currently available. Recent EASL\u2013EASD\u2013EASO guidelines recommend tirzepatide for MASLD patients with obesity, T2D, or cardiometabolic risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tirzepatide combines potent metabolic effects with significant hepatic improvements, positioning it as a promising therapy for MASLD\/MASH. Although long\u2010term and phase III data are still needed, current evidence supports tirzepatide as a key component of modern metabolic liver disease management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jdr\/1853763","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:51:34Z","timestamp":1775883094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tirzepatide in Metabolically Dysfunctional\u2010Associated Steatohepatitis (MASH): A Bibliometric and Evidence\u2010Based Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2540-7781","authenticated-orcid":false,"given":"Ileana","family":"Pantea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8748-5332","authenticated-orcid":false,"given":"Angela","family":"Repanovici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.04.002"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.04.031"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12040826"},{"key":"e_1_2_13_4_2","first-page":"1204","article-title":"Statin Therapy in Patients With Diabetes and Hepatitis C","volume":"61","author":"Rusu E.","year":"2013","journal-title":"Farmacia"},{"key":"e_1_2_13_5_2","unstructured":"StefanD. S. LixandruD. andBajkoD. et al.The Evolution of Resting Metabolic Rate and Body Composition After 6 and 12 Months of Lifestyle Changes in Obese Type 2 Diabetes Patients 2017 INTERDIAB 2017: Diabetes Mellitus in Internal Medicine. Bucharest: International Conference on Interdisciplinary Management of Diabetes Mellitus and its Complications."},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v18.i1.111954"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2025.0212"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v17.i2.113149"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116723"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867330666230106103202"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-022-01746-8"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101090"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14831"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2024.2436595"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/10742484221146371"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-1892"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2401943"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60111761"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare10050773"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2024.2310070"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000001254"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570180820666230130153219"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2023.102935"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/goae029"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2025.2546812"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2023.2181074"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i48.5205"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-024-06196-3"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.5152\/tjem.2022.22003"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.038"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155741"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-66998-8"}],"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jdr\/1853763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/jdr\/1853763","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jdr\/1853763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:51:43Z","timestamp":1775883103000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/jdr\/1853763"}},"subtitle":[],"editor":[{"given":"Hamza","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/jdr\/1853763"],"URL":"https:\/\/doi.org\/10.1155\/jdr\/1853763","archive":["Portico"],"relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"value":"2314-6745","type":"print"},{"value":"2314-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1853763"}}