{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:17:00Z","timestamp":1784956620007,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":353,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015801","name":"Anhui Provincial Quality Engineering Project","doi-asserted-by":"publisher","award":["2023jyxm1231"],"award-info":[{"award-number":["2023jyxm1231"]}],"id":[{"id":"10.13039\/100015801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Limited data are available about the epidemiological characteristics and the risk factors for amputation, particularly in developing countries from Asia, especially in China.<\/jats:p><jats:p><jats:bold>Objective:<\/jats:bold> We aim to investigate the age features of patients with Type 2 diabetic foot ulcers (DFUs) and analyze the critical influencing factors predicting lower extremity amputation and major amputation.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Data were retrieved from the electric medical record system to identify patients aged &gt;\u200918 years with Type 2 DFU from January 1, 2017, to December 31, 2023. A logistic regression model was adopted to analyze the risk factors for amputation and major amputation.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Nine hundred eighteen patients with Type 2 DFU were eligible for our study, 68.2% of whom were male. In patients with Type 2 diabetes in the hospitals we studied, the prevalence of Type 2 DFU was 1.07%. A majority of patients with DFU were in the 70\u201379 age group in the winter season, and deaths also peaked in this age group. A total of 38.8% of patients aged 50\u201359 years underwent amputation. Vascular CTA, complications, history of amputation, and infection sites were the important contributing factors in patients with DFU lower extremity amputation. History of amputation and hemoglobin were the main influencing factors of patients with major amputation resulting from DFU.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Most patients with DFU were in the age group of 50\u201359 years, but the majority of deaths occurred in the 70\u201379\u2010year age group. Several factors influence the amputation, and those findings provide new insights into the relationship between the severity of narrowed blood vessels and the likelihood of amputation.<\/jats:p>","DOI":"10.1155\/jdr\/2380337","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T16:47:01Z","timestamp":1734626821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Age Characteristics of Patients With Type 2 Diabetic Foot Ulcers and Predictive Risk Factors for Lower Limb Amputation: A Population\u2010Based Retrospective Study"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1365-8883","authenticated-orcid":false,"given":"Yuanying","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9450-0475","authenticated-orcid":false,"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9341-2043","authenticated-orcid":false,"given":"Yu","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3268"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13569"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.23937\/2377-3634\/1410120"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12263"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.8.1869"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13039"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fcl.2010.05.001"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-020-00433-9"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05278-2"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2020-001355"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0462"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1504"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10578"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/383275"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-1596"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.967733"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2021.09.041"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13935"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202201_27883"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2022.1519"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2022.08.004"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5439521"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-019-0345-y"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0240588"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2022.108221"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192114212"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2021.06.006"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19074111"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239236"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1024904"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2022.109972"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2014.04.011"},{"key":"e_1_2_13_35_2","unstructured":"YeL. Analysis of clinical characteristics and influencing factors of amputation in inpatients with diabetic foot ulcer [Ph.D. thesis] 2021 Anhui Medical University."},{"key":"e_1_2_13_36_2","first-page":"123","article-title":"Analysis of influencing factors of amputation and survival prognosis in diabetic foot patients","volume":"26","author":"Chen J.","year":"2018","journal-title":"Chinese Journal of Diabetes"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-1816"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14840"}],"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jdr\/2380337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T17:06:03Z","timestamp":1735837563000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/jdr\/2380337"}},"subtitle":[],"editor":[{"given":"Munmun","family":"Chattopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/jdr\/2380337"],"URL":"https:\/\/doi.org\/10.1155\/jdr\/2380337","archive":["Portico"],"relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"value":"2314-6745","type":"print"},{"value":"2314-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2380337"}}