{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:17:02Z","timestamp":1790806622799,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":123,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014592","name":"Insulet Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Automated insulin delivery (AID) systems aim to safely optimize glycemic outcomes; however, data in the new\u2010onset type 1 diabetes (T1D) period are limited. We evaluated safety and glycemic outcomes of Omnipod 5 AID System use in the new\u2010onset period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective observational analysis of youth at a single center who initiated Omnipod 5 within 90 days of T1D diagnosis. Safety outcomes included diabetic ketoacidosis (DKA) and severe hypoglycemia. Continuous glucose monitoring (CGM) metrics and insulin delivery data were analyzed across the first 3 months of use and between pediatric age groups (&lt;6\u2010year\u2010olds, 6 to &lt;12\u2010year\u2010olds, and 12 to &lt;18\u2010year\u2010olds).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 74 youth initiating Omnipod 5 within 90 days of T1D diagnosis, there was no occurrence of DKA or severe hypoglycemia in the first 3 months of AID system use. The time\u2010weighted average glucose target value on the device setting was 118.8\u2009mg\/dL (6.6\u2009mmol\/L) with a median of 97% time in Automated Mode over 3 months. Median total daily insulin was 7.4 units (45.5% basal) in &lt;6\u2010year\u2010olds, 11.4 units (48% basal) in 6 to &lt;12\u2010year\u2010olds, and 25.7 units (45% basal) in 12 to &lt;18\u2010year\u2010olds. The median glucose management indicator (GMI) was 7.1% (54\u2009mmol\/mol) and time in range (70\u2013180\u2009mg\/dL, 3.9\u201310.0\u2009mmol\/L) was 72.1% with minimal hypoglycemia: 1.0% Level 1 time below range (TBR, 54\u201369\u2009mg\/dL, 3.0\u20133.8\u2009mmol\/L) and 0% Level 2 TBR (&lt;54\u2009mg\/dL, &lt;3.0\u2009mmol\/L).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These real\u2010world observational data from youth with new\u2010onset T1D using a tubeless AID system indicate safety and favorable glycemic outcomes with AID system initiation early after diagnosis. Future studies should assess the long\u2010term glycemic and quality of life impact of early AID system adoption.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jdr\/2896084","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:38:14Z","timestamp":1777963094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety and Glycemic Outcomes Among Youth With New\u2010Onset Type 1 Diabetes Using a Tubeless Automated Insulin Delivery System"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0440-3339","authenticated-orcid":false,"given":"Daniel J.","family":"DeSalvo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0922-1547","authenticated-orcid":false,"given":"Natalie M.","family":"Linde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Sickler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Villegas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4335-6763","authenticated-orcid":false,"given":"Marzia","family":"Cescon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-1331"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-024-06165-w"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-2359"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-0172"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2020.0546"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1581"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-S006"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/dci19-0028"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.33590\/emj\/10310168"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12374"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0578"},{"key":"e_1_2_12_12_2","doi-asserted-by":"crossref","first-page":"S283","DOI":"10.2337\/dc25-S014","article-title":"Standards of Care in Diabetes\u201414. Children and Adolescents: Standards of Care in Diabetes\u20142025","volume":"48","author":"American Diabetes Association Professional Practice Committee","year":"2025","journal-title":"Diabetes Care"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0337"},{"key":"e_1_2_12_14_2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/pedi.12525","article-title":"Nighttime is the Worst Time: Parental Fear of Hypoglycemia in Young Children With Type 1 Diabetes","volume":"19","author":"Van Name M. 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