{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:08:18Z","timestamp":1788955698618,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":251,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200932"],"award-info":[{"award-number":["82200932"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The study aimed to investigate the following: (1) whether early\u2010pregnancy serum polyunsaturated fatty acid (PUFA) species are associated with the risk of gestational diabetes mellitus (GDM); and (2) whether lysophosphatidylcholine (LPC)18:0 may statistically explain these associations in Chinese pregnant women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a 1:1 age\u2010matched case\u2013control study of 486 pregnant women nested within a prospective cohort in Tianjin, China. Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression analysis was used to identify the PUFA species independently associated with GDM. Conditional logistic regression was conducted to obtain odds ratios (ORs) and their 95% confidence intervals (CIs). Sobel mediation analysis was used to assess the potential statistical role of LPC18:0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among five PUFA species that differed significantly between cases and controls, arachidonic acid (AA, 20:4) and docosahexaenoic acid (DHA, 22:6) were selected and further analyzed. High AA (\u2265\u20093.63\u2009nmol\/mL) and DHA (\u2265\u20090.59\u2009nmol\/mL) were associated with increased GDM risk, with multivariable\u2010adjusted ORs of 2.89 (95% CI: 1.84\u20134.54) and 2.90 (95% CI: 1.82\u20134.63), respectively. These associations were stronger among women with pre\u2010pregnancy overweight\/obesity (AA, OR: 5.32, 95% CI: 2.48\u201311.42; DHA, OR: 3.39, 95% CI: 1.65\u20136.99). Further adjustment for high LPC18:0 substantially attenuated the associations of AA (OR: 0.90, 95% CI: 0.45\u20131.80) and DHA (OR: 0.97, 95% CI: 0.51\u20131.85) with GDM risk, with Sobel test\n                      <jats:italic>p<\/jats:italic>\n                      \u2009values &lt; 0.0001.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher serum AA and DHA levels in early pregnancy were associated with increased GDM risk. LPC18:0 may statistically explain part of these observed associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jdr\/3535965","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:39:40Z","timestamp":1788953980000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High Serum Polyunsaturated Fatty Acids for the Increased Risk of Gestational Diabetes Mellitus Through LPC Pathways: A Prospective Nested Case\u2013Control Study in China"],"prefix":"10.1155","volume":"2026","author":[{"given":"Shumin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9941-8083","authenticated-orcid":false,"given":"Xinli","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhong","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5011-7985","authenticated-orcid":false,"given":"Weiqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinnan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1325-1194","authenticated-orcid":false,"given":"Juliana C. N.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6172-8017","authenticated-orcid":false,"given":"Gang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4901-3545","authenticated-orcid":false,"given":"Zhijie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9462-7992","authenticated-orcid":false,"given":"Xilin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2777-2572","authenticated-orcid":false,"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.11.003"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-s206"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00734-y"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-2361"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.741"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12442"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13072421"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2021-002326"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-024-01714-1"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.01.046"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/met.2016.0124"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020518-114444"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.5c00482"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa058"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121029"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1848"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016341003801706"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz296"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15238"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1207\/s15327906mbr3001_3"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2021.102318"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0693"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2017.01.002"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27051677"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/life13081656"}],"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jdr\/3535965","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/jdr\/3535965","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jdr\/3535965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:39:42Z","timestamp":1788953982000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/jdr\/3535965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/jdr\/3535965"],"URL":"https:\/\/doi.org\/10.1155\/jdr\/3535965","archive":["Portico"],"relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"value":"2314-6745","type":"print"},{"value":"2314-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3535965"}}