{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:55:05Z","timestamp":1786121705736,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":217,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetic peripheral neuropathy (DPN) is a common and disabling complication of Type 2 diabetes mellitus (T2DM). Emerging evidence suggests that elevated serum uric acid (SUA) may associate with microvascular complications; however, data from sub\u2010Saharan Africa remain limited. We examined the association between hyperuricemia and DPN among adults with T2DM in northern Tanzania.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a hospital\u2010based cross\u2010sectional analytical study at a tertiary diabetes clinic from November 2024 to April 2025. Adults aged \u2265\u200918 years with established T2DM were consecutively recruited. DPN was assessed using the Toronto Clinical Scoring System (TCSS), with DPN defined as TCSS \u2265 6. Fasting SUA was classified as elevated at \u2265\u2009340\u2009\n                      <jats:italic>\u03bc<\/jats:italic>\n                      mol\/L in women and \u2265\u2009420\u2009\n                      <jats:italic>\u03bc<\/jats:italic>\n                      mol\/L in men. Multivariable logistic regression estimated adjusted odds ratios (aORs). Receiver operating characteristic (ROC) analysis assessed discriminatory performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 321 clinic attendees, 220 participants met eligibility criteria and were analyzed (mean age &lt; 65 years: 69.1%; male: 53.2%). DPN prevalence was 51.8% (114\/220). Elevated SUA was present in 52.7% and was strongly associated with DPN (aOR 5.89, 95% CI 3.01\u201311.51,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Diabetes duration \u2265\u20095 years (aOR 3.81,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.016), overweight status (aOR 2.18,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.034), elevated fasting glucose (aOR 2.20,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.022), and low HDL (aOR 2.10,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.040) were independently associated with DPN. Elevated total cholesterol was inversely associated (aOR 0.36,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003). SUA demonstrated moderate discrimination for DPN (AUC 0.773).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hyperuricemia was independently associated with prevalent DPN in this Tanzanian study. SUA may represent a clinically accessible marker for neuropathy risk stratification in resource\u2010limited settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jdr\/4174684","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T06:08:32Z","timestamp":1786082912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Uric Acid and Diabetic Peripheral Neuropathy in Type 2 Diabetes Mellitus: A Cross\u2010Sectional Study From Northeastern Tanzania"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4665-0345","authenticated-orcid":false,"given":"Raya S.","family":"Hamad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William 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