{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:49:16Z","timestamp":1792147756498,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":288,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study is to compare the standardized associations, cross\u2010sectional discrimination, and distributional robustness of 13 routinely derived metabolic indices for International Diabetes Federation (IDF)\u2010defined metabolic syndrome (MetS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 9660 Chinese adults who underwent routine health examinations at Peking University Shenzhen Hospital between August 2024 and March 2026. Associations were assessed using logistic regression with standardized indices and restricted cubic splines, and overall and prespecified subgroup discrimination were evaluated using receiver operating characteristic analyses. Fully adjusted analyses included age, sex, low\u2010density lipoprotein cholesterol, total bilirubin, blood urea nitrogen, creatinine, and uric acid. Robustness was examined after 1st\u201399th percentile winsorization using self\u2010standard deviation (self\u2010SD) and fixed main\u2010sample standard deviation (fixed main\u2010SD) standardization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 9660 participants, 1635 had MetS (16.93%). The cardiometabolic index (CMI) showed the strongest standardized association (odds ratio (OR) per standard deviation increment, 19.437), followed by the triglyceride\u2010glucose waist circumference index (TyG\u2010WC; OR, 16.332). TyG\u2010WC had the highest overall area under the receiver operating characteristic curve (AUC, 0.934; 95% confidence interval (CI), 0.929\u20130.939) and the highest AUC in 9 of 11 prespecified strata. After winsorization, TyG\u2010WC retained strong standardized associations under self\u2010SD and fixed main\u2010SD scaling (ORs, 17.181 and 18.638, respectively) and stable discrimination (AUC, 0.935), whereas CMI, the lipid accumulation product (LAP), visceral adiposity index (VAI), and triglyceride\u2010total cholesterol\u2010body weight index (TCBI) showed substantial scale dependence. All indices showed nonlinear associations (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 13 indices differed in association strength, discrimination, and distributional robustness. TyG\u2010WC showed the most balanced overall profile and maintained strong discrimination across most prespecified subgroups. These findings support the further evaluation of TyG\u2010WC in routine health examination settings. Further validation in independent multicenter populations is required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jdr\/4648598","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:19:28Z","timestamp":1792145968000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Routinely Derived Metabolic Indices for IDF\u2010Defined Metabolic Syndrome in Chinese Adults: A Cross\u2010Sectional Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3632-1134","authenticated-orcid":false,"given":"Qiuman","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Physical Examination Peking University Shenzhen Hospital  Shenzhen China  pkuszh.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3775-1249","authenticated-orcid":false,"given":"Fen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Physical Examination Peking University Shenzhen Hospital  Shenzhen China  pkuszh.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7771-1734","authenticated-orcid":false,"given":"Yongjian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physical Examination Peking University Shenzhen Hospital  Shenzhen China  pkuszh.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9111-935X","authenticated-orcid":false,"given":"Qianqian","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Physical Examination Peking University Shenzhen Hospital  Shenzhen China  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