{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:04:57Z","timestamp":1777867497428,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":119,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["yzjj2023ms19"],"award-info":[{"award-number":["yzjj2023ms19"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetic retinopathy (DR), the most common ocular complication of diabetes mellitus, is a leading cause of blindness among the working\u2010age population. Its pathogenesis is mainly related to blood\u2013retinal barrier destruction, inflammation, retinal neuron damage, oxidative stress, and genetic immune factors. This study is aimed at elucidating the role and underlying mechanism of histone deacetylase 3 (HDAC3) in DR\u2010associated retinal neuronal injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, the mouse model of diabetes was induced by intraperitoneal injection of streptozotocin (STZ) dissolved in sodium citrate buffer. At 4, 8, and 12 weeks, the thickness of the retinal and photoreceptor layers was observed by hematoxylin\u2013eosin staining, and the expression of HDAC3 in the mouse retina was evaluated by immunohistochemical staining. In vitro, 661W cells were cultured under high\u2010glucose conditions to mimic the diabetic environment. To investigate the role of HDAC3, its expression was inhibited using either the specific inhibitor RGFP966 or HDAC3\u2010specific small interfering RNA (HDAC3\u2010siRNA). Subsequently, the levels of oxidative stress and apoptosis were detected to analyze the mechanism by which HDAC3 influences photoreceptor damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>With the prolongation of diabetes duration, the thickness of the retinal layer and photoreceptor cell layer becomes thinner, and the expression of HDAC3 in the retina increases. In vitro, HDAC3 expression, apoptosis, and oxidative stress were increased in 661W cells treated with high glucose. Critically, inhibition of HDAC3 using either RGFP966 or HDAC3\u2010siRNA effectively attenuated the high\u2013glucose\u2010induced apoptosis and oxidative stress in these cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that HDAC3 is associated with apoptosis and oxidative stress of DR photoreceptors, and the inhibition of HDAC3 can reduce apoptosis and oxidative stress of DR photoreceptors. It is suggested that epigenetic therapy of HDAC3 inhibitors may have therapeutic value in the prevention and treatment of DR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jdr\/5747601","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:21:27Z","timestamp":1777544487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhibition of HDAC3 Expression Alleviates High\u2013Glucose\u2010Induced Photoreceptor Cell Apoptosis and Oxidative 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